Dietmar H. Wittmann, M.D., Ph.D., FACS

CURRICULUM VITAE

Table of Contents

CURRICULUM VITAE

Dietmar H. Wittmann, M.D., Ph.D., FACS

PERSONAL INFORMATION

EDUCATION

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS

FACULTY APPOINTMENTS

DEVELOPMENT AND DIRECTORSHIP OF SURGICAL CRITICAL CARE PROGRAM

1989-1998 Surgical Critical Care Fellowship Program which is accredited by Residency Review Committee representing the American Board of Surgery, the American College of Surgeons and the American Medical Association Council on Medical Education

HOSPITAL AND ADMINISTRATIVE APPOINTMENTS

SPECIALTY CERTIFICATION AND OTHER CERTIFICATION

ATLS Certification :

1989 Advanced Trauma Life Support Certification (ACS, Committee on Trauma)

1991 Instructor Advanced Trauma Life Support Certification

1998 ATLS Instructor re-Certification (ACS, Committee on Trauma)

MEDICAL LICENSE

1970 #7417 Germany/European Union

1989 #30772 Wisconsin

MEMBERSHIP IN PROFESSIONAL SOCIETIES

EDITORIAL BOARDS AND CONSULTANT

NATIONAL AND INTERNATIONAL ADVISORY COMMITTEES AND/OR ACTIVITIES

RESEARCH GRANT AWARDS

Principal Investigator

Budget 1998/99: Account: 330,783

A Multicenter Phase III Study to Assess the Safety and Efficacy of Bactericidal/Permeability Increasing Protein (rPBI21) in Patients with Hemorrhage Due to Trauma (Principal Investigator)

Budget 1998/99: Account: 330.831

A Prospective, Multicenter, double-blind, Randomized Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of MK-0826 Versus Piperacillin/tazobactam in the Treatment of Complicated Intra-Abdominal Infections in Hospitalized Adults (Principal Investigator, Froedtert Hospital)

Budget 1998/99: Account: 330.831

A Prospective, Multicenter, double-blind, Randomized Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of MK-0826 Versus Piperacillin/tazobactam in the Treatment of Complicated Intra-Abdominal Infections in Hospitalized Adults (Principal Investigator, VA Hospital)

Budget 1998/99: Account: 330.831

A Prospective, Multicenter, double-blind, Randomized Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of MK-0826 Versus Piperacillin/tazobactam in the Treatment of Complicated Soft Tissue Infections in Hospitalized Adults (Principal Investigator, VA Hospital)

Budget 1998/99: Account: 330.xxx

Linezolid vs. Nafcillin Sodium / Dicloxacillin Sodium for the Treatment of Complicated Skin and Soft Tissue Infections: A Comparator-Controlled Study of Intravenous Therapy with Optional Oral Continuation.

Budget 1998/99: Account: 3330400

Open Study of Synercid (quinupristin/dalfopristin, RP59500) for Emergency Use (Infections Due to Resistant Bacteria, Treatment Failure or Treatment-Intolerant Patients) (Principal Investigator)

Budget 1997/98: Account: 3330284

A double blind, multicenter, comparative study of timentin and Imipenem/cilastatin in the prevention of infections in patients with penetrating intestinal injury (Principal Investigator)

Budget 1997/99: Account: 3330323

Staged abdominal Repair for Peritonitis, Pancreatitis, and Trauma; Multicenter Trial (Principal Investigator)

Budget 1997/98: Account: 3330340

Measurement of cytokines an nitric oxide in human defense failure syndrome. (Principal Investigator)

Budget 1997/98: Account: 330262

Influence of IgG versus placebo on mortality, Infection and saved quality adjusted life years (Principal Investigator)

Budget 1997/98: Account: 3330365

Grant for Visiting Professor, Surgical Critical Care Symposia and other educational activities from various sources ( Principal Investigator)

Budget 1996/97 Account330382

A Comparison of Ampicillin/Sulbactam versus cefoxitin for the prevention of infectious complications following penetrating abdominal trauma (Principal Investigator)

Budget 1999/00: Account: 3330396

Quality of Life Assessment after Trauma: Development of improved outcome criteria as a foundation for therapeutic improvement. ( Principal Investigator)

Budget 1997/98: Account: 3330400

Pharmacokinetics and antimicrobial tissue penetrations utilizing a new extraction model.

(Principal Investigator)

Budget 1996/97: Account: 3330404

Randomized, placebo controlled trial of E5-antiendotoxin monoclonal antibody in patients with severe sepsis (Principal -investigator)

Budget 1997/98: Account: 3330 xxx

Timing and duration of antibiotic therapy in intraabdominal infections. (rats) Project # 226-95-1

Budget 1996/97: Account: 3330 xxx

Anastomotic healing in peritonitis: Staples versus hand sewn anastomosis in a dog model. (Grant written, but not submitted. (grant written, not submitted)

  Co-Investigator

Budget 1997/98:

A randomized, double blind, placebo-controlled trial of the presumptive use of fluconazole in febrile ICU patients at risk for fungal infections (co-investigator)

Budget 1997/98:

A randomized, double blind, placebo-controlled, multicenter, two active dose level study of betafectin PGG-glucan for the prevention of serious infections in patients at high risk for infection. (co-investigator)

Budget 1997/98: 3330323

A double blind, prospective, randomized, multicenter study comparing clinafloxacin (CI-960) and imipenem/cilastatin for the treatment of complicated intra-abdominal infections. (co-investigator)

Budget 1997/98:

NIH: Motility and Propulsion in the Diabetic Gut (coinvestigator)

NEW METHODS/INNOVATIONS

 HOSPITAL COMMITTEES (LAST 3 YEARS)

1989-present Pharmacy and Therapeutics Committee, MCMC, FMLH

1989-present Infection Control Committee, MCMC, FMLH

MEDICAL COLLEGE TEACHING

Lectures to 3rd year medical students: Complications in Surgery, Peritonitis; Acute Abdomen

Instruction of 3rd and 4th year medical students daily;

Trauma & Emergency Surgery Advisor of 3rd year medical students.

Instructor of MD-PhD tract students

HONORS

BIBLIOGRAPHY

ARTICLES

Original contributions in italic

1975

1. Müller-Wieland K, Wittmann DH. Are the chronically ill a traffic risk? (German) Kraftfahrt und Verkehrsrecht 11:223-237, 1970.

2. Adler E, Wittmann DH. Acute hemorrhage of gastroduodenal ulcer managed without adequate blood transfusions. (German) Zbl Chir 100:598-602, 1975.

1976

3. Wittmann DH, Schröder HJ. Diagnostic and therapeutic problems with gallstone ileus. (German) Act Chir 11:247-602, 1976.

4. Wittmann DH, Boje H, Eckardt K, Niebuhr D. Prognostic significance of mammary gland papillomatosis. (German) Beiträge zur Mammachirurgie Chir Praxis, Hans Marseille Verlag München, pp 11-16, 1976.

1977

5. Wittmann DH, Eggert A. A new method to obtain high concentrations of gastrin for quantitative analysis of different human gastrin fractions. (German) Chirurg 48:159-160, 1977.

6. Eggert A, Seidel H, Wittmann DH. Pharmacokinetics of methylmethacrylate monomere from bone cement. (German) Chirurg 48:316-318, 1977.

7. Wittmann DH, Eggert A. Pathogenesis of gallstone ileus.(German) Chirurg 48:678-680, 1977.

8. Eggert A, Kirschner H, Schröder J, Wittmann DH. The lymphostatic edema of the upper extremity after breast cancer therapy. (German) Med Klin 72:2106-2113, 1977.

9. Eggert A, Seidel H, Wittmann DH. The intermittent Chilaiditi syndrome: Differential diagnosis of the acute abdomen. (German) Act Chir 12:357-366, 1977.

1978

10. Eggert A, Randel G, Wittmann DH. Pyodermia fistulans sinifica. (German) Chir Praxis 23:537-541, 1978.

11. Wittmann DH, Schimmel G, Seidel H. Long term treatment of chronic bone infections with cephalexin. (German) Therapiewoche 28:8946-8956, 1978.

1979

12. Eggert A, Freitag V, Schimmel G, Wittmann DH. Technique of intra-operative bacteriological diagnosis of bile tract infection. (German) Ärztl Lab 25:79-82, 1979.
3. Eggert A, Wittmann DH, Schröder HJ, Schimmel G. Significance of intraoperative bacteriological findings in biliary disease. (German) Münch med Wschr 119:955-958, 1979.
4. Wittmann DH, Schassan H-H, Seidel H . Investigations upon the availability of cefuroxin in bone and wound fluid. (German) Med Welt 30:227-232, 1979.
5. Wittmann DH, Welter J, Freitag V. Indications and initial treatment results of antimicrobial therapy with the combination of mezlocillin and oxacillin for severe infections. (German) Klinikarzt 8:689-692, 1979.
6. Wittmann DH, Eckardt K, Randel G. The risk of cancer in papillomatous disease of the breast Verh Dtsch Krebs Ges 2:64-65, 1979.
7. Wittmann DH, Welter J, Schassan H-H. Investigations on the peritoneal penetration of beta-lactam antibiotics to be considered in the treatment of intra-abdominal infections. (German) In R Häring (Hrsg) Peritonitis TM-Verlag Bad Oyenhausen pp 85-92, 1979.

1980

Wittmann DH, Schassan H-H, Freitag V. Pharmacokinetic studies and results of a clinical trial with cefotaxime. Current Chemotherapy and Infectious Diseases, American Society for Microbiology Washington DC, 1980, pp 114-116.

Seidel H, Eggert A, Wittmann DH. Cardiogenic shock after implantation of bone cement. (German) Anaesthesiol Intensivmed 125:391-400, 1980

Freitag V, Friedrich O, Kopf PO, Wittmann DH. Bacteriologic sensitivity of cefotaxime - a new semi-synthetic cephalosporin. (German) Infection 8:S397-400, 1980.

Wittmann DH. Chemotherapeutic principles in difficult-to-treat infections in surgery. I. Peritonitis. Infection 8:323-329, 1980.

Wittmann DH. Chemotherapeutic principles in difficult-to-treat infections in surgery. II. Bone and joint infections. Infection 8:330-333, 1980.

Pröpper H, Wittmann DH. Therapy of peptic ulcer disease in the light of therapy with H2 blockers and proximal selective vagotomy. (German) Berliner Arzteblatt 93:353-362, 1980.

Pröpper H, Wittmann DH. Current aspects of peptic ulcer therapy: opinion of internal medicine versus surgery. (German) Der praktische Arzt 15:1940-1969, 1980.

Kirschner H, Wittmann DH. Educational recommendations regarding the intern year based on the practical experience in the two surgical departments at Altona General Hospital. (German) Hamburger Arzteblatt 3:181-184, 1980.

Wittmann DH, Erich M, Freitag V, Kopf PO, Kult K, Pröpper H, Welter J. Antimicrobial therapy for severe infections. (German) Ther d Gegenw 119:558-570, 1980.

Wittmann DH, Schassan H-H, Freitag V. Pharmacokinetic investigations upon the availability of cefamandole in bone and joint infections. (German) Ther d Gegenw 119:1422-1435, 1980.

Wittmann DH, Schassan H-H, Schreiner P. Pharmacokinetic investigations upon the penetration of mezlocillin and azlocillin into bone and wound fluid. (German) In W Siegenthaler und H Weuta (Hrsg): International Symposium Alcylureido-Penicilline, Wien. Excerpta Medica, Amsterdam, 1980, pp 86.

Wittmann DH, Schassan H-H. Piperacillin concentrations in serum, bone, bile and interstitial and peritoneal fluid. (German) In Siegenthaler W, Benkert K (Eds) Antimicrobielle Chemotherapy: piperacillin, Verlag Informed, Gräfelfing, 1980.

Wittmann DH, Schassan H-H, Welter J, Seidel H. Pharmacokinetic investigations upon the penetration of cefotaxime into central and peripheral compartments. (German) Münch med Wschr 122:637-641, 1980.

Wittmann DH, Schassan H-H, Freitag V. Correlation of pharmacokinetic-bacteriological findings with clinical results of antimicrobial therapy for peritonitis. (German) In B Wiedemann (Ed): Die Resistenz Gegenüber Beta-lactam-antibiotika. Bad Honnef, Germany, pp 242-249, 1980.

1981

32. Wittmann DH, Schassan H-H, Kohler F, Seibert F. Pharmacokinetic studies of ceftazidime in serum bone bile tissue fluid and peritoneal fluid. J Antimicrob Chemother 8:S293-297, 1981.
23. Wittmann DH, Schassan H-H, Kohler F, Seidel H. Penetration of moxalactam into bone. (German) Unfallchirurgie 7:142-146, 1981.
24. Wittmann DH, Freitag V, Welter J. Infections in abdominal surgery: treatment results with moxalactam. Infection 9:191-196, 1981.
25. Wittmann DH, Schassan H-H, Seidel H. Pharmacokinetics of mezlocillin and azlocillin and their penetration into bone and tissue fluid. (German) Arzneim-Forsch/Drug Res 31:1157-1162, 1981.
26. Welter J, Wittmann DH, Freitag V. Ticarcillin therapy of risk patients with infections due to pseudomonas aeruginosa. J Int Med Res 9:44-51, 1981.
27. Wittmann DH. Bone level of cefoperazone. (German) Münch med Wschr 123:S110-112, 1981.
28. Stute J, Schassan H-H, Wittmann DH. Drug kinetics of the combination of mezlocillin and oxacillin into skin and soft tissue. (German) Klinikarzt 10:29-31, 1981.
29. Wittmann DH, Schassan H-H. Influence of protein binding on tissue penetration of isoxalolyl-and aclylureidopenicillins. Current Chemother Immunother, American Society for Microbiology Washington DC, 1981, pp 653.
30. Wittmann DH, Schassan H-H. Bone concentrations of six new beta-lactam-antibiotics. Current Chemother Immunother, American Society for Microbiology Washington DC, 1981, pp 628-629.
31. Stute J, Schassan H-H, Wittmann DH, Küchlin J. Pharmacokinetic studies and results of a clinical trial with combination therapy with mezlocillin and oxacillin. Current Chemother Immunother, American Society for Microbiology Washington DC, 1981, pp 652-654.
32. Stübner G, Dethlefson H, Wittmann DH. Distribution of pepsin-cleaved human immunoglobulin in serum and peritoneal fluid in patients with peritonitis. (German) Die gelben Hefte 21:21-25, 1981.
33. Wittmann DH. Suitable preoperative precautions to reduce the risk of post-operative infection following abdominal procedures. (German) Umweltmed 3:38-40, 1981.
34. Wittmann DH, Erich M, Freitag V, Kopf PO, Kult H, Pröpper H, Welter J. Pharmacokinetic studies and results of a clinical trial with cefotaxime. (Italian) Chemiother Antimicrobica 9:113-120, 1981.
35. Wittmann DH, Welter J. Peritonitis due to perforation of the upper gastrointestinal tract.(German) In Kempf, P (Ed), Behandlung der Peritonitis. W Zuckschwert-Verlag, München, 1981, pp 113-120.
36. Welter J, Wittmann DH. Peritonitis in the elderly patient.(German) In Kempf, P (Ed) Behandlung der Peritonitis. W Zuckschwert-Verlag, München, 1981, pp 155-165.
37. Wittmann DH, Welter J. Antimicrobial therapy of peritonitis.(German) In Kempf, P (Ed), Behandlung der Peritonitis. W Zuckschwert-Verlag, München, pp 55-65, 1981.

1982

48. Wittmann DH, Schassan H-H. Basics of antimicrobial therapy for peritonitis. (German) Langenbecks Arch Chir 358:589-590, 1982.
49. Wittmann DH, Welter J, Schassan H-H. Penetration of mezlocillin into peritoneal fluid. (German) Infection 10:S196-200, 1982.
40. Wittmann DH, Schassan H-H . The distribution of moxalactam in serum bone tissue fluid and peritoneal fluid. Rev Inf Dis 4:S610-S616, 1982.
41. Welter J, Wittmann DH, Schassan H-H. Pharmacokinetic investigations upon the penetration of mezlocillin into pleural fluid. (German) Infection 10:S201-204, 1982.
42. Eggert A, Teichmann W, Wittmann DH. Pathological implication of duodenal diverticula. Surg Gynecol Obstet 154:62-64, 1982.
43. Welter J, Wittmann DH, Schassan H-H. Pharmacokinetic investigations of the penetration of mezlocillin into the pleural fluid. Int J Clin Pharm Res 2:265-268, 1982.
44. Wittmann DH. Comparison of cephalosporins for peritonitis.(German) Fortschr Antimicrob Antineoplast Chemother 1:175-184, 1982.
45. Wittmann DH. Clinical experience with piperacillin used for intra-abdominal infection. (German) In W Stille W Siegenthaler H Knothe D Adam (Ed) Klinische Bewertung von Antibiotika, Statikon-Verlag München, 1982, pp 51-56.
46. Wittmann DH. Chemotherapeutic principles for infectious problems in surgery: intra-abdominal infections. (German) Acta Chir Austriaca Suppl 43:22-23, 1982.
47. Wittmann DH, Bargmann H-J, Eckardt K, Eggert A, Freitag V. Reduction of infection after colon procedures: results of a prospective randomized double-blind study. (German) In P Eckert und L Zwank (Ed): Perioperative Antibiotikatherapie, W Zuckschwert Verlag München, 1982, pp 84-101.
48. Seidel H, Wittmann DH. Perioperative administration of antibiotics for open lower leg fractures. (German) In P Eckert und L Zwank (Ed): Perioperative Antibiotikatherapie, W Zuckschwert Verlag München, 1982, pp 166-167.
49. Wittmann DH, Randel G, Saul Th, Fock R, Laufs R. Serumkinetics and bone concentrations of ceftriaxone in the elderly. (German) In L Dettli H Lode P Naumann KH Spitzy und H Schönfeld (Eds), Ceftriaxon Ein Neues Parenterales Cephalosporin. Editiones Roche, Basel Grenzach-Whylen, 1982, pp 191-200.
50. Bauernfeind A, Wittmann DH. Retention of fosfomycin in organic bone-hydroxylapatite. (German) In KH Spitzy und D Adam (Eds), Fosfomycin- Ein neueartiges Antibiotikum Internationales Symposium Salzburg, 1982. Pmi-Pharm-and-Medical-Information-Verlags-GmbH Frankfurt/M, Zürich, 1982.
51. Wittmann DH. Perioperative prophylaxis with antibiotics.(German) In D Höffler (Ed), Moderne Antibiotika-Therapie. Futuramed Verlag, München, pp 5-7, 1982.
52. Wittmann DH. Antibiotic prophylaxis in surgery. In RM Van derHeide (Ed), DePlaatsbepaling Van de Cefalosporinen in het Klinisch Antibioticumbeleid, pp 61-69, Oedip Nederland BV Medische Uitgeveri Apeldoorm, 1982.

1983

63. Wittmann DH, Kellinghusen C, Welter J, Freitag V. Intra-abdominal infections: results of a randomized prospective trial. (German) Act Chir 18:229-353, 1983.
54. Wittmann DH, Schassan H-H. Penetration of eight beta-lactam antibiotics into peritoneal fluid. Arch Surg 118:205-212, 1983.
55. Wittmann DH, Berghoff D, Reynders-Frederix V, Schassan H-H. Significance of hydroxylapatite with regard to determination of antimicrobial bone concentrations. (German) Arzneim Forsch/Drug Res 33:423-426, 1983.
56. Winker H, Dörtemann J, Wittmann DH. Prophylaxis of infections after elective colon surgery. (German) Chirurg 54:272-277, 1983.
57. Wittmann DH, Kirschner H, Luetkens S. Long term results of elective and urgent highly selective vagotomy. (German) Langenbecks Arch Chir 361:(243)671-672, 1983.
58. Wittmann DH, Schassan H-H. Bioavailability of antibiotics in peritonitis. (German) Schweiz Rundschau Med 72:363-368, 1983.
59. Wittmann DH. Chemotherapeutic principles of bone and joint infections. (German) Der Krankenhausarzt 56:925-928, 1983.
60. Welter J, Herden H-N, Wittmann DH. Combined therapy with cefoxitin and azlocillin in critical care medicine. (German) Klinikarzt 12:217-225, 1983.
61. Bauernfeind A, Wittmann DH. Bacteria specific pathogenic factors of the microflora in peritonitis. (German) Fortschr Antimicrob Antineoplast Chemother. 2:431-436, 1983.
62. Jeckstadt P, Wittmann DH. A prognostic index for intra-abdominal infections. (German), Fortschr Antimicrob Antineoplast Chemother 2:517-525, 1983.
63. Wittmann DH, Kellinghusen C, Frommelt L. Peritonitis after perforation of sigmoid diverticula. Fortschr Antimikrob Antineoplast Chemother 2:535-542, 1983.
64. Wittmann DH, Frommelt V. Metronidazole in intra-abdominal infections. (German) In Werner H, Wittmann DH, Riemann JF (Eds) Metronidazole, Fortschr Antimicrob Antineoplast Chemother 2:703-706, 1983.
65. Wittmann DH. Bone concentrations of cefoperazone compared with other new cephalosporins. In Y Ueda and E Kass (Ed), Proceedings of Sixth International Cefoperazone Symposium, Experta Medica, Princeton, 1983, pp 131-142.
66. Welter J, Fock R, Wittmann DH. On the ability of mezlocillin to penetrate the cerebrospinal fluid. In KH Spitzy and K Karrer (Eds), Pseudomonas Penicillins. Proceedings of 13th International Congress of Chemotherapy, Wien, 93:49-52, 1983.
67. Saul Th, Wittmann DH, Fock R, Laufs R. Serum bone and tissue fluid concentrations of ceftriaxone. In KH Spitzy und K Karrer (Eds), Ceftriaxone. Proceedings of 13th International Congress of Chemotherapy, Wien, 100:40-43, 1983.
68. Wittmann DH, Saul Th, Frommelt L, Fock R. Bone concentrations of moxalactam and its clinical significance. In C Törholm and DH Wittmann (Eds) Osteomyelitis - Experimental and Clinical Studies. Proceedings of 13th International Congress of Chemotherapy, Wien, 66:14-17, 1983.
69. Kuipers Th, Saul Th, Wittmann DH, Zabel G, Fock R. Serum and bone concentration of netilmicin in elderly. In C Törholm and DH Wittmann (Eds), Osteomyelitis - Experimental and Clinical Studies. Proceedings of 13th International Congress of Chemotherapy, Wien, 66:18-21, 1983.
70. Wittmann DH, Bauernfeind A. The uptake of antibiotics by inorganic bone. In C Törholm and DH Wittmann (Eds), Osteomyelitis - Experimental and Clinical Studies Proceedings of 13th International Congress of Chemotherapy, Wien, 66:8-10, 1983.
71. Wittmann DH. Prophylaxis in general surgery. Infect Surg 2:825-830, 1983.
72. Wittmann DH. The role of cephalosporins in surgical infections. In J Klastersky (Ed), Nosocomial Infections, Institut Jules Bordet Centre des Tumeurs de l`Universite Libre de Bruxelles, Belgium, pp 128-142, 1983.
73. Wittmann DH. Development and goals of the Study Group Peritonitis. (German) In DH Wittmann (Ed), Intraabdominelle Infektionen. Fortschr Antimicrob Antineoplast Chemother 2:311-317, 1983.
74. Wittmann DH. Bacteriological findings in different forms of peritonitis. (German) In DH Wittmann (Ed), Intraabdominelle Infektionen. Fortschr Antimicrob Antineoplast Chemother 2:423-429, 1983.
75. Wittmann DH. Basis for calculated chemotherapy of intra-abdominal infections. (German) In: DH Wittmann (Ed), Intraabdominelle Infektionen. Fortschr Antimicrob Antineoplast . Chemother 2:467-478, 1983.
76. Wittmann DH. Introduction: Peritonitis after Perforation of a Diverticulum. (German) In DH Wittmann (Ed), Intraabdominelle Infektionen. Fortschr Antimicrob Antineoplast Chemother 2:525-526, 1983.
77. Wittmann DH. Clinical use and pharmacokinetics of metronidazole.(German) In Werner H, Wittmann DH, Riemann JF (Eds), Metronidazole. Fortschr Antimicrob Antineoplast Chemother 2:757-782, 1983.

1984

88. Wittmann DH. A clinical evaluation of piperacillin in intra-abdominal infections. Clin Ther 6:SA 35-44, 1984.
79. Bauernfeind A, Wittmann DH. Uptake of 4-quinolones into inorganic bone and antibacterial activity in the bone. Chemiotherapia 4:S2 487-488, 1984.
80. Wittmann DH, Kuipers Th, Fock R, Fedder J. Pharmacokinetics of imipenem/cilastatin in young healthy volunteers and elderly. (German) Z Antimikrob Antineoplast Chemother 2:89-97, 1984.

1985

91. Teichmann W, Eggert A, Wittmann DH, Böcker W. The zipper: new method for temporary abdominal closure. (German) Chirurg 56:173-178, 1985.
82. Wittmann DH, Teichmann W, Frommelt L. Importance of pathogenic bacteria with regard to therapy of suppurative peritonitis. (German) Chirurg 56:363-370, 1985.
83. Wittmann DH, Frommelt L. The efficacy of cefotaxime in gram-positive surgical infections. Infection 13:S37-42, 1985.
84. Wittmann DH, Teichmann W. Etappenlavage and treatment of pathogenic bacteria.(German) Langenbecks Arch Chir 366:629-630, 1985.
85. Wittmann DH. Directed and calculated therapy of surgical infections with imipenem/cilastatin. (German) Fortschr Antimicrob Antineoplast Chemother 4:1063-1076, 1985.
86. Wittmann DH. Calculated chemotherapy of biliary and intra-abdominal infections with ceftazidime. (German) Fortschr Antimicrob Antineoplast Chemother 4:729-749, 1985.
87. Wittmann DH. Penicillins and peritonitis. (German) Z Antimicrob Antineoplast Chemother 3:127-141, 1985.
88. Wittmann DH. Calculated antibiotic therapy of infections following abdominal trauma. In P Dineen (Ed), Surgical and Antimicrobial Management of Trauma Patients. Infections in Surgery, 4:S21-23, 1985.
89. Wittmann DH. Antibiotic concentration in tissue fluid during the vulnerable period as rational basis for prophylaxis of post operative infections: Focus on infections after operations of the colon biliary tree and bone. In J Ishigami (Ed), Recent Advances in Chemotherapy, University of Tokyo Press, pp 189-192, 1985.
1. Wittmann DH. Directed and calculated therapy of surgical infections with imipenem/cilastatin. (German) Arzneimittelpraxis 15:661-670, 1985.

1986

101. Teichmann W, Wittmann DH, Andreone PA. Scheduled reoperations (Etappenlavage) for diffuse peritonitis. Arch Surg 121:147-152, 1986.
102. Teichmann W, Wittmann DH. The principle of Etappenlavage as a new therapy in acute abdominal surgery (trauma and emergencies). (German) Langenbecks Arch Chir 369:799-800, 1986.
103. Wittmann DH, Kuipers TH, Fock R, Höll M, Bauernfeind A. Bone concentration of imipenem/cilastatin. (German) Infection 14:S130-137, 1986.
104. Wittmann DH, Kotthaus E. Further methodological improvements in antibiotic bone concentration measurements: penetration of ofloxacin into bone and cartilage. Infection 14:S270-273, 1986.
105. Wittmann DH. Staphylococci: an infectious problem in surgery? (German) Fortschr antimicrob antineoplast Chemother 5:1333-1339, 1986.
106. Wittmann DH, Hegerfeld R, Hübner A. Comparison of imipenem/cilastatin with other beta-lactam antibiotics in bone infections. (German) Fortschr antimicrob antineoplast Chemother 5:311-320, 1986.
107. Wittmann DH. Prophylaxis of post-operative infections: single dose or multiple dosing. (German) Krankenhausarzt 59:515-534, 1986.
108. Wittmann DH . Infection control and quality assurance in surgery. (German)Krankenhaus-Hygiene und Infverh. 8:66-74, 1986.
109. Wittmann DH, Müller M. Patient Stratification in Intra-abdominal Infection. ICI Educational Workshop, Cairo, October 27, 1986, pp 5-8

1987

110. Wittmann DH, Müller M. Patient stratification in intra-abdominal infection. Chemiotherapia 6S:5-8, 1987.
12. Wittmann DH, Teichmann W, Müller M. Development and validation of peritonitis indices Altona. (German) Langenbecks Arch Chir 372:834-835, 1987.
13. Wittmann DH. Infection control in surgery. (German) Hospitalis 57:650-659, 1987.
14. Adam D, Daschner F, Hahn H, Stille W, Wittmann DH. Infection prophylaxis in surgery: use of antimicrobials. (German) Chir Gastroenterol mit Interdisziplinären Gesprächen TM-Verlag, Hameln, FGR, 1987.
15. Norby SR, Kager L, Tally FP, Wittmann DH. An international panel on intraabdominal infections. In SR Norrby (Ed) Intraabdominal Infections, DFY Publisher Minimonograph, New York, 1987.
16. Wittmann DH, Müller M. The PIA II score for intra-abdominal infections. In JL Meakins, H Troidl (Eds): Risk Factor Analysis and Severity Scoring: Foundations for Research and Clinical Therapeutics in Intra-abdominal Infections, Proc. of the International Congress on Intraabdominal Infections, Adelphi Communications, Macclesfield, UK, 1987.
17. Wittmann DH. Basis for calculated chemotherapy of intra-abdominal infections. (German) In DH Wittmann (Ed), Intraabdominelle Infektionen. Fortschr Antimicrob Antineoplast Chemother 2:471A, 1987.
18. Adam D, Daschner F, Hahn H, Stille W, Wittmann DH. Infection prophylaxis in surgery. (German) TM-Verlag, Bad Oyenhausen, 1987

1988

118. Wittmann DH. Microbiology and antimicrobial therapy for intra-abdominal infections. (Thai) In N Vaitayangura, A Paosawadsi (Eds), Evolution in Surgery, Royal College of Surgeons of Thailand, Bangkok Medical Publisher, Bangkok, Thailand, pp. 339-358, 1988.
119. Wittmann DH. Use and abuse of antibiotics worldwide: summary report from the WHO working group on prophylaxis of postoperative wound infections. Infection 17:46-57, 1989.
21. Wittmann DH, Bergstein JM, Aprahamian C. Etappenlavage for diffuse peritonitis. (German) Beitr Anäst Intensivemed, 30:199-221, 1989.

1990

121. Nyström PO, Bax R, Dellinger EP, Dominioni L, Knaus WA, Meakins JL, Ohmann Ch, Solomkin JS, Wacha H, Wittmann DH. A proposed standard for trials on intra-abdominal infection. World J Surg 14:148-156, 1990.
23. Wittmann DH, Aprahamian C, Bergstein JM. Etappenlavage: Advanced diffuse peritonitis managed by planned multiple laparotomies utilizing zippers, slide fastener, and Velcro analogue for temporary abdominal closure. World J Surg 14:218-226, 1990.
24. Wittmann DH, Koltowski P, Oleszkiewicz J, Walker AP. Infectious complications after 807 biliary tract operations and results of a randomized blinded study comparing cefoxitin versus ampicillin plus an inhibitor of beta-lactamases. Infection 18:41-47, 1990.
25. Aprahamian CA, Walker ST, Quebbman, EJ, Bergstein JM, Sasse, EA, Wittmann DH. Use of medical center utilities by human immunodeficiency virus (HIV) positive patients. J Trauma 30:745-747, 1990.
26. Aprahamian C, Wittmann DH, Bergstein JM, Quebbman EJ. Temporary abdominal closure (TAC) for planned relaparotomy (Etappenlavage) in trauma. J Trauma 60: 719-723, 1990
27. Bergstein JM, Kramer A, Wittmann DH, Aprahamian C, Quebbeman EJ. Pseudomembranous colitis: How useful is endoscopy? Surg Endosc 4:217-219, 1990.

1991

127. Gregory JS, Bergstein JM, Aprahamian C, Wittmann DH, Quebbeman EJ. Comparison of three methods of rewarming from hypothermia: advantages of extracorporeal blood warming. J Trauma 31:1247-1252, 1991.
29. Wittmann DH, Bergstein JM: Post-operative necrotizing wound infection and bacterial synergistic gangrene. Postgraduate General Surgery, 3:131-134, 1991.
30. Aprahamian C, Wittmann DH. Operative management of peritonitis. Infection 19;453-455, 1991.
31. Wittmann DH, Bergstein JM, Frantzides C. Calculated empirical antibiotic treatment of acute surgical infections. Infection 19:S345-350, 1991.
32. Wittmann DH, Condon RE. Prophylaxis of postoperative infections. Infection, 19;S337-343, 1991
33. Condon RE, Wittmann DH: The Use of Antibiotics in General Surgery. Mosby Year Book. Current Problems in Surgery 28:803-949, 1991.

1992

133. Frantzides CT, Lianos EA, Wittmann D, Greenwood B, Edmiston CE: Prostaglandins and modulation of small bowel myoelectric activity. Am J Physiol 262:G488-497, 1992.
35. Bergstein JM, Blair J-F, Edwards J, Towne JB, Wittmann DH, Aprahamian C, Quebbeman EJ: Pitfalls in color flow duplex ultrasound for screening of suspected arterial injuries in penetrated extremities. J Trauma 33:395-402, 1992.
36. Wittmann DH, Schein M, Nystroem P-O. Open packing laparostomy in the septic abdomen. In: T Ruedi (Ed.) The State of the Art of Surgery 1991/1992. International Society of Surgery, CH-4153 Reinach BL1, Switzerland, pp 30 - 34, 1992
37. Wittmann, DH: Die Antibiotika-Therapie bei der sekundären Peritonitis: Kommentar auf Anforderung der Schriftleitung zur Arbeit von Hannes Wacha. Chemotherapie Journal 2:115-118 , 1992.

1993

137. Wittmann DH, Aprahamian C, Bergstein JM, Edmiston CE, Frantzides CT, Quebbeman EJ, Condon RE: A burr-like device to facilitate temporary abdominal closure in planned multiple laparotomies. Eur J Surg 159:75-79, 1993.
39. Page CP, Bohnen JMA, Fletcher JR, McManus AT, Solomkin JS, Wittmann DH: Antimicrobial Prophylaxis for Surgical Wounds: Guidelines for Clinical Care. Arch Surg 128:79-88,1993.
40. Ohmann C, Wittmann DH, Wacha H, and the Peritonitis Study Group. Prospective evaluation of prognostic scoring systems in peritonitis. Eur J Surg 159:267-274, 1993.
41. Wittmann DH, Syrrakos B, Wittmann MM: Advances in the Diagnosis and Treatment of Intra-abdominal Infections. In R.L. Nichols, R.M. Nyhus, C. Judge (Eds.). Surgical Sepsis: 1993 and Beyond. J.B. Lippincott, Philadelphia, Problems in General Surgery, 10:604-627, 1993.
42. Schein M. Wittmann DH. Antibiotics in abdominal surgery: the less the better [Editorial] European Journal of Surgery. 159(9):451-3, 1993 Sep.

1994

141. Wittmann DH, Aprahamian C, Bergstein JM, Bansal N, Wallace JR, Wittmann MM: Staged Abdominal Repair Compares Favorably to Conventional Operative Therapy for Intra-abdominal Infections when Adjusting For prognostic Factors with a Logistic Model. Theoretical Surg (Now European J Surg) 25:273-284, 1994.
43. Holzheimer R, Molloy RG, Wittmann DH: Postoperative Complication: A New Risk Factor for Recurrence in Crohn's disease. European J Surg 160:129-135, 1994.
44. Wittmann DH, Gores JA, Rangabashyam N, Sayek, I. Laparostomy, Open Abdomen, Etappenlavage, Planned Relaparotomy and Staged Abdominal Repair: Too Many Names for a New Operative Method. In Ruedi (Ed), State of the Art of Surgery, 1993/1994, International Society of Surgery, Reinach, Switzerland. pp. 23-27, 1994.

1995

144. Wittmann DH: Current concepts in the treatment of infections in surgery. Diag Microbiol Infect Dis 22;273- 282, 1995

145. Schein M, Assalia A, Eldar S, Wittmann DH: Is mechanical bowel preparation necessary before primary colonic anastomosis? An experimental study. Dis Colon Rectum 38:1-6,1995

Aprahamian CA, Schein M, Wittmann DH: Cefotaxime and metronidazole in the severe intraabdominal infection. Diag Microbiol Infect Dis 22:183-188, 1995.

Wittmann DH: The Role of cefotaxime in the treatment of surgical infections. Diag Microbiol Infect Dis 22:173-183, 1995.

Ma OJ, Mateer JR, Ogata M, Kefer MP, Wittmann DH, Aprahamian C: Prospective Analysis of A Rapid Trauma Ultrasound Exam Performed by Emergency Physicians. J Trauma 38:879-885

Wittmann DH, Schein M, Condon RE: Antibiotic Prophylaxis in Abdominal Wall Hernia Surgery: Never, Always, or Selectively? Problems in General Surgery 12, 47-55, 1995.

Holzheimer RG, Schein M, Wittmann DH: (335b) Inflammatory response in peritoneal exudate and plasma of patients undergoing planned relaparotomy for severe secondary peritonitis. Arch Surg 130; 1314-1320, 1995.

Schein M, Wittmann DH, Aprahamian C, Condon RE: The abdominal compartment syndrome: The physiological and clinical consequences of elevated intra-abdominal pressure. J Am Coll Surg 180:744-753, 1995.

Wittmann DH, Schein M, Seoane D, Aprahamian C, Komorowski RA, Georgakas K, Quebbeman EJ, Wallace JR, Condon RE: Pyoderma Fistulans Sinifica (Fox Den Disease): A distinctive soft-tissue infection. 1995 Clin Infect Dis 21:162-170.

Bergstein JM, Baker EJ, Aprahamian CA, Schein M, Wittmann DH. Soft Tissue Abscess Associated with Parenteral Drug Abuse: Presentation, Microbiology and Treatment. The American Surgeon 12; 1105-1108, 1995

Ludwig KA, Quebbeman, EJ, Bergstein JM, Wallace JR, Wittmann DH, Aprahamian C. Shock-Associated Right Colon Ischemia and Necrosis. J Trauma 70;1171-1174, 1996

Bergstein JM, Gregory JS, Quebbeman EJ, Aprahamian C. Wittmann, DH, Wallace, JR. Extracorporeal Rewarming: Technological Advances and experience in 29 patients. J Trauma 70; 791-792x, 1996

Schein M, Solomkin J, Wittmann DH. (344): Cytokines in bacterial peritonitis. Current Opinion in Surgical Infections 3:123-127; 1995

Wittmann DH: (341) Newer methods of operative therapy for peritonitis: Open abdomen, planned relaparotomy or staged abdominal repair: Is there a difference? (in Japanese including Commentary by Japanese author) Churchill Communications Osaka: Japan. Clinical Infection & Chemother 1:40-41, 1995.

1996

157. Wittmann DH, Schein M, Condon RE: Management of Secondary Peritonitis. Annals of Surgery 224;10-18, 1996
59. Wittmann MM, Wittmann AM, Wittmann DH; AIDS, Emergency Operations, and Infection Control. Infect Control Hosp Epidemiol 17;532-538, 1996
60. Schein, M, Wittmann DH, Holzheimer, R, Condon, RE:Hypothesis: Compartmen-talization of Cytokines in Intra-abdominal Infection. Surgery 119;694-700, 1996.
61. Wittmann, DH: Abdominal Compartment Syndrome. What is that? How do we treat it?. In JP Kim, RE Condon Proceedings of the 15th World Congress of the Collegium Internationale Chirurgiae Digestivae, Seoul, Korea, September 11-14, 1996. Monduzzi Editore S.p.A., Bologna, Italy, 1996. pp 161-176
62. Schein M, Wittmann DH: The Abdominal Compartment Syndrome Following Peritonitis, Abdominal Trauma, and Operations. Complications in Surgery 15(5), 1996 and http://www.medscape.com/SCP/CIS/1996/v15.n05/s1009.schein/s1009.schein.html
63. Wittmann, DH: (348b) Pharmacokinetic basis for short courses of antimicrobial therapy. Eur J Surg, Suppl 576:19-23; 1996.
64. Schein M, Wittmann DH, Lorenz W: Forum statement: A plea for selective and controlled postoperative antibiotic administration. Eur J Surg, Suppl 576:66-69; 1996.
65. Wittmann, DH, Schein, M: Let us shorten antibiotic prophylaxis and therapy in surgery. American Journal of Surgery. 172(6A):26S-32S, 1996.
66. Schein M. Wittmann DH. Adjuvant treatments for serious infections [letter; comment]. [Comment. Letter] Critical Care Medicine. 24(3):549-51, 1996
66. Fischer JE, Dellinger EP, Fischer J, Bohnen JMA, Davis JM, Wittmann DH, Dunn DL, Solomkin JS, Fry DE: The status of anti-infectives in surgery in 1996: A roundtable discussion. American Journal of Surgery. 172(6A):49S-61S, 1996. [#361b]
67. Schein M, Wittmann DH, Wittmann AM, Condon REC. Abdominal contamination, infection and Sepsis; a continuum. Brit. J. Surg. 84;269-272, 1997 [# 351]
68. Wittmann, MM, Wittmann, AM, Wittmann, DH; AIDS, Emergency Operations, and Infection Control. Infect Control Hosp Epidemiol 17;532-538, 1996 [# 354b]

169. Slakey DP, Johnson CP, Cziperle DJ, Roza AM, Wittmann, DH, Gray DWR, Roake JA, Britton, J, Morris PJ,, Adams MB: Management of Severe Pancreatitis in Renal Transplant Recipients. Ann. Surg 225, 217-222, 1997
170. Wittmann DH. Wallace J; The Various Leaving-the-Abdomen-Open Techniques for Advanced Severe Peritonitis: Mesh, Zippers, Artificial Burr, and Other Methods. World Journal of Surgery 22; submitted 1998. ( # 381)
171. Wittmann, D.H., R.N. Jones, J. Malledant, G. Privitera, Cefotaxime in the Prophylaxis and Treatment of Surgical Infection. Journal of Chemotherapy, 9, Suppl.2,:19-33, 1997
172. Wittmann DH., Operative and Non-Operative Therapy of Intra-abdominal Infections. Infection 26: xxx-xxx 1998. Accepted, in press (#388c)
173. Schein, M, Wittmann, DH, Lorenz, W. Practice Guidelines for the Duration of Antibiotic Treatment in Surgery of the Abdomen. Official guideline of the Deutsche Gesellschaft fuer Chirurgie (German Surgical Association) published under Principles of Surgery/E 66 in 1997. The German title is as follows: Grundlagen der Chirurgie, "Leitlinien zur Dauer der antibiotischen Therapie bei chirurgischen Infektionen des Abdomens." 1996
174. Wittmann, Cefotaxime in the Prophylaxis and Treatment of Surgical Infection. Research and Clinical Forums, Vol. 19;35-46, 1997 (#363a)
175. Wittmann, DH, Discussions in: Updates and New Perspectives: Proceedings of a clinical symposium held at Kowloon Shangri-La Hotel, Hong Kong, June 10, 1996, ed. R. Jones. Research and Clinical Forums, 19:20-21, 35-36 and 46-48, 1997 (#363a)

     1998

176. Wittmann DH, Scope and Limitations of Anti-Microbial Therapy of Sepsis. Langenbeck’s Archive for Surgery. 383; 15-25. (#389)
177. Practice Management Guidelines For Prophylactic Antibiotics In Penetrating Abdominal Trauma East Guidelines http://www.east.org/tpg/chap9body.html
178. Wittmann, DH. Das Kompartment Syndrom der Bauchhoehle; Der Chirug (#364)
179. Wittmann DH. When to discontinue antibiotics in planned relaparotomies. Invited Commentary on Visser, et al: Predictors of recurrences of fulminant bacterial peritonitis after discontinuation of antibiotics in open management of peritonitis. Eur. J Surg 1998; xxx. In press.
180. Wittmann DH. Invited Commentary on Taylor et al.: Antibiotic Prophylaxis and Open Groin Hernia Repair. World J Surg 22/10, October 1998. In press.
181. Wittmann DH. Invited Commentary on Gonzales et al.: Effectiveness of Collagen-Gentamicin Implant in the Treatment of "Dirty" Abdominal Wounds. World J Surg. In press.
182. Wittmann DH. Appendicitis. Invited State-of-the-Art paper for Clin. Infect. Disease, 1998

Will be continued

BOOK CHAPTERS

1. Wittmann DH. Infection control and quality assurance. (German) Eilbeker Gespräche der Gesundheitsbehörde Hamburg, 1986.
2. Wittmann DH. The value of antibiotics in the treatment of post-traumatic bone and joint infections. (German) In A Braun (Ed), Heidelberger Orthopädie Symposium. Springer Verlag, Berlin, 1987.
3. Condon RE, Wittmann DH. Approach to patients with intra-abdominal infections. In SL Gorbach, JG Bartlett, NR Blacklow (Eds), Infectious Diseases in Medicine and Surgery. W.B. Saunders, 1991.
4. Wittmann DH, Frantzides CT. Diverticulitis. In SL Gorbach, JG Bartlett, NR Blacklow (Eds), Infectious Diseases in Medicine and Surgery. W.B. Saunders, pp. 682-686, 1991.
5. Wittmann DH. Intra-abdominal Infection. In I. Sayek, Textbook of Surgery. Ankara: Gunes Kitabevi, pp. 1067-1083, 1991.
6. Wittmann DH. Surgical Infections and Antibiotic Therapy. In R.E. Condon, L.M. Nyhus (Eds), Manual of Surgical Therapeutics, 8th edition, Chapter 21, Little, Brown and Company, Boston, pp 330-368, 1992.
7. Aprahamian C, Wittmann DH, Bergstein JB, Quebbeman EJ: Gastrointestinal Complications. In Mattox KL (Ed), Complications of Trauma, Pages 465-480, Churchill Livingston, Inc., Naperville, IL, 1993.
8. Wittmann DH, Walker A, Condon RE: Peritonitis and Intraabdominal Infection. In Schwartz, Shires, Spencer (Eds.); Principles of Surgery, Sixth Edition, McGraw-Hill, Inc., Chapter 32, Pages 1449-1483, 1993.
9. Wittmann DH. Antibiotic prophylaxis in laparoscopic surgery. In C. Frantzides (ed.) Laparoscopic Surgery, Mosby , St. Louis, Chapter 13, pp 198-223, 1994.
10. Wittmann DH. Immunological consequences of antibiotic therapy. In Holzheimer R: Recent Developments in Immunology: Potential Clinical Impact on Surgery and the Treatment of Infections. Berlin, Heidelberg, New York: Springer Verlag, 1994.
11. Condon RE, Wittmann DH. Surgical Infection. In PJ Morris, Ed. Textbook of Surgery, Oxford University Press, pp. 27-44, 1994.
12. Wittmann, DH, Schein, M. (#322) Chapter 3: Problems Encountered in the Surgical Intensive Care Unit (SICU): In. RE Condon, LM Nyhus (eds.) Manual for Surgical Therapeutics, 9th Edition, Little Brown and Company, Boston - New York - Toronto - London, pp. 110-121, 1996
13. Wittmann, DH (#321). Chapter 24: Surgical Infections and Antibiotic Therapy. In. RE CONDON, LM NYHUS (eds.) Manual for Surgical Therapeutics, 9th Edition, Little Brown and Company, Boston - New York - Toronto - London. pp. 367-380, 1996
14. Wittmann, DH.: Newer methods of operative therapy for peritonitis: In Nyhus LM, Baker RJ, Fischer JE, (Eds) Mastery of Surgery, Third edition Little Brown and Company, Publishers, Boston, pp, 1996/97
15. Wittmann DH, Condon RE,: Cytokines in Patients with Peritonitis, (Ed.) E. Ferraz, Textbook of Surgery (Brazil), MEDSI Editora Medica e Cientifica Ltda. pp 171-184, 1997.
16. Wittmann DH. Operative management of peritonitis. (Ed.) E. Ferraz, Textbook of Surgery (Brazil), MEDSI Editora Medica e Cientifica Ltda. pp 387-420, 1997.
17. Wittmann DH, Schein, M.: Tertiary Peritonitis (Ed.) E. Ferraz, Textbook of Surgery (Brazil), MEDSI Editora Medica e Cientifica Ltda. pp 421-426, 1997
18. Condon RE, Wittmann DH Intraabdominal Infections. In SL Gorbach, JG Bartlett, NR Blacklow (Eds). Infectious Diseases in Medicine and Surgery. W.B. Saunders, pp. 793-800, 1998 (2nd ed.).
19. Wittmann DH, Schein, M, Frantzides CT. Diverticulitis. In SL Gorbach, JG Bartlett, NR Blacklow (Eds) Infectious Diseases in Medicine and Surgery. W.B. Saunders, pp. 828-833, 1998 (2nd ed.).
20. Wittmann DH: Der Chirurg und AIDS. In: Lippert H (ed.) Praxis der Chirurgie. Stuttgart: Georg Thieme Verlag, 1997.
21. Wittmann DH. Intra-abdominal Infection. In I. Sayek, Textbook of Surgery. 2nd Edition, Gunes Kitabevi, Ankara: pp.1408-1436, 1997.
22. Wittmann DH, Condon RE. Surgical Infection. In PJ Morris, Ed. Textbook of Surgery, 2^nd Edition, Oxford University Press, in press, 1998
23. Wittmann DH, Condon RE. Prevention of Surgical Infection. In T Hau, E. Farthmann (Ed). Surgical Infection, Mc Graw Hill Press, in press, 1998
24. Solomkin, JS, Wittmann DH, Barie PS, West M, Peritonitis. In Schwartz al. (ed), Principles of Surgery, Seventh Edition, New York, McGraw-Hill, Inc., Chapter 32, 1998.

PUBLISHED DISSERTATIONS and BOOKS

1. Wittmann DH. EXPERIMENTAL INVESTIGATIONS UPON THE AFFINITY OF CARBON MONOXIDE TO HEMOGLOBIN OF RATS, RABBITS AND HUMANS. (German) Inaugural Dissertation, Universität Düsseldorf, 1970.

2. Paschen,U, Wegener, OH, Wittmann DH Mueller-Plathe,O: 200 Jahre Allgemeines Krankenhaus Altona 1784-1984 Ernst Kabel, Hamburg, 1984

3. Wittmann DH. THERAPY OF PERITONITIS. (German) Habilitationsschrift, Universität Hamburg, 1985.

4. DH Wittmann, Lüthy R. (Eds). BONE INFECTIONS. (German) Proc Wissenshaftliches Programm der Jahrestagung der Paul Ehrlich Gesellschaft für Chemotherapie eV Okt 86 Frankfurt/M, 1986.

5. DH Wittmann (Ed). INTRA-ABDOMINAL INFECTIONS: ANALYSIS AND TREATMENT. (German) Robert Pfützner Verlag, München, 1986.

6. Wittmann DH. INTRA-ABDOMINAL INFECTIONS: ANALYSIS AND TREATMENT. (Spanish), Robert Pfützner Verlag, München, 1988, ISBN:84-7625-018-5.

7 Wittmann DH. IDENTIFICATION AND ANALYSIS OF NOSOCOMIAL INFECTIONS IN THE FEDERAL REPUBLIC OF GERMANY. (German) Infratest Gesundheitsforschung, München, FRG, 1989.

8. Wittmann DH. INTRA-ABDOMINAL INFECTIONS: PATHOPHYSIOLOGY AND TREATMENT. Marcel-Dekker Publisher, New York, (1990). Monograph

9 Wittmann, DH: Cefotaxime: Benefits in Surgery, Monograph published by Wells Medical Ltd., Kent England, 1996

10. Wittmann, DH. Peritonitis, Springer, New York, Heidelberg, Berlin. Book not finalized 1999

EDITORIALS, LETTERS TO EDITORS, REVIEWS

• Wittmann DH. Editorial comment on Sepsis in surgery: reducing the risk. In S Karran (Ed) Antibiotic Prophylaxis and Surgery, Adis Press, Auckland, New Zealand, 1987.
• Wittmann DH. Symposium on Intraabdominal infections - Editorial Introduction. World J Surg 14:145-147, 1990.
• Wittmann DH. Intraabdominal infection. (Letter to the Editor), World J Surg. 15:408-410, 1991.
• Wittmann, DH., Rangoonwala, R., Marget, W (eds.). Treatment and Prophylaxis of Infections. Infection 19;447-464, 1991.
• Neu, HC, Wittmann, DH, Rangoonwala R (Eds.). Cefotaxime - Efficacy and Safety - A Decade of International Experience. Infection 19;S305-345, 1991.
• Wittmann DH. Invited Commentary on: Simmen HP, Battaglia H, Kossmann T, Blaser J: Effect of pH in Peritoneal Fluid on Outcome of Aminoglycoside Treatment in Intra-Abdominal Infections. In World J Surg 17: 393-397, 1993.
• Schein M, Wittmann DH. Antibiotics in abdominal surgery: The less the better. Eur J Surg, 159:451-454, 1993.
• Wittmann, DH. Review of Monograph Peritonitis by Donald E. Fry (Ed.), Mount Kisco, NY, Futura, 1993. Review in The New England Journal of Medicine, July 14, 1994.
• Wittmann DH. Invited Commentary on: American Association for the Surgery of Trauma (AAST), Trauma Care Quality Indicators: An Analysis of Outcome in Statewide Trauma Registry, J Trauma 37:573-574, 1994.
• Wittmann, DH: Comment on Nicholas. RL et al: Prospective Alterations in Therapy for penetrating abdominal trauma. Arch Surg 129;55-64, 1993 Surgical Infections: Index and Reviews 1:1; page 4, 1993
• Wittmann DH. Comment on Simmen HP Battaglia H, Kossmann T, Blaser J: Effect of pH in Peritoneal Fluid on Outcome of Aminoglycoside Treatment in Intra-Abdominal Infections. In World J Surg 17: 393-397, 1993. Surgical Infections: Index and Reviews 1:2;4 1993
• Wittmann DH. Comment on: Nespoli A, Ravizzini C, Trivella M, Segala M: The Choice of Surgical Procedure for Peritonitis Due to Colonic Perforation. Arch Surg 1993; 128:814-818.. Surgical Infections: Index and Reviews 1:3;8, 1993
• Wittmann DH. Comment on: Huizinga WKJ, Baker LW: The Influence of Splenectomy on Infection Morbidity After Colonic and Splenic Injuries. Eur J Surg 1993;159:579-584, and:
• Wittmann DH: Comment on Duke BJ, et al. Transfusion Significantly Increases the Risk for Infection After Splenic Injury. Arch Surg 1993;128:1125-1132. Surgical Infections: Index and Reviews 1:4;13, 1993.
• Wittmann DH. Comment on: Kressner U, et al.: Intraoperative Colonic Lavage and Primary Anastomosis -- An Alternative to Hartmann Procedure in Emergency Surgery of the Left Colon. Eur J Surg 1994;160:287-292; Pakkastie TE, et al: Anastomotic Leakage After Anterior Resection of the Rectum. Eur J Surg 1994;160:293-297; and Bardini R, et al.: World J Surg 1994;18:373-378. Surgical Infections: Index and Reviews 2:2;5, 1994.
• Wittmann DH. Comment on H. New et al.: Emerging trends in antimicrobial resistance. Eur. J Surg 160. Suppl 573 7-18, 1994. Surgical Infections: Index & Reviews, 2:3;9, 1994
• Wittmann DH. Comment on Wiedemann, B. et al. :Mechanisms of Quinolone Resistance. Infection 22;S73-79, 1994, and Susceptibility of clinical bacterial isolates in the United Stated, Infection 22;S73-79, 1994 and three more papers. Surgical Infections: Index & Reviews, 2:3;9, 1994
• Wittmann DH: Comment on: Armstrong JH, Barcia PJ: Pilonidal Sinus Disease: The Conservative Approach. Arch Surg 1994;129:914-918. Surgical Infections: Index and Reviews 3:1;12, 1995
• Wittmann DH. Comment on: Bergeron MC, M. Quellette: Diagnosing Bacterial Infectious Disease in One Hour: An Essential Upcoming Revolution: Infection 23:69-72, 1995. Surgical Infections: Index and Reviews 3:3;13 1995..
• Wittmann, DH. Comment on: Surgical antibiotic prophylaxis and clostridium difficile toxin positivity: Arch Surg 130; 989-993, 1995 Surgical Infection, Index and Review 3:4;6 1995
• Wittmann, DH. (362a) Comment for on Hau, T et al: Planned Relaparotomy vs. Relaparotomy on Demand in the Treatment of Intra-abdominal Infections. Arch Surg. 130; 1193-1197, 1995, Surgical Infection - Index & Review 4:1;5 1996
• Wittmann, DH. Comment on de Vera ME et al: Antibiotic Resistant Enterococci and the Changing Face of Surgical Infections Surgical Infections: Index & Reviews, 4:II quarter,1996. Surgical Infections: Index & Reviews, 4:2;10,1996
• Wittmann DH: Comment on Wang, X, et al: Gut origin sepsis, macrophage function, and oxygen extraction associated with acute pancreatitis in the rat. on World J Surg, 20, 299-308, 1996. Surgical Infections: Index & Reviews, 4:3;6, 1996
• Wittmann, D.H. Comment on Hau, T et al: Planned Relaparotomy vs. Relaparotomy on Demand in the Treatment of Intra-abdominal Infections. Arch Surg. 130; 1193-1197 1995. Surgical Infection - Index & Review, 4: 4;12 1996
• Schein M, Wittmann, DH, Lorenz,, W. (348a) . Discussion Forum on Antibiotic treatment of post operative abdominal infections. Europ. J. Surg. 162 Supplement. 576; 5-75, 1996
• Wittmann DH, Schein M, (348b) editorial comment on Condon RE: Microbiology of Intraabdominal Infection and Contamination. Europ. J. Surg. 162 Supplement 576; 9-13, 1996
• Wittmann DH, Schein M, editorial comment on Pollock AV: At what point is infection cured but inflammation persists? Europ. J. Surg. 162 Supplement 576; 13-16, 1996
• Wittmann DH, Schein M, editorial comment on Bergstein JM: The role of Shock . Europ. J. Surg. 162 Supplement 576; 16-18, 1996
• Wittmann DH, Schein M, editorial comment on Künneke M, et al: Cardio-vascular adverse effects of antimicrobials. Europ. J. Surg. 162 Supplement 576; 24-28, 1996
• Wittmann DH, Schein M, editorial comment on Dellinger EP: Undesired effects of antibiotics and future studies. Europ. J. Surg. 162 Supplement 576; 24-28, 1996
• Wittmann DH, Schein M, editorial comment on Solomkin JS: The future: randomized prospective studies. Europ. J. Surg. 162 Supplement 576; 33-35, 1996
• Wittmann DH, Schein M, editorial comment on Lechleuthner A, et al: Minimal Antibiotic Therapy: Technology Assessment Instead of Clinical Trials. Europ. J. Surg. 162 Supplement 576; 36-38, 1996
• Wittmann DH, Schein M, editorial comment on Saadia R, et al: Antibiotics and the Gut. Europ. J. Surg. 162 Supplement 576; 39-41, 1996
• Wittmann DH, Schein M, editorial comment on Nyström PO: Transition from contamination to infection; implications in colonic surgery. Europ. J. Surg. 162 Supplement 576; 42-46, 1996
• Wittmann DH, Schein M, editorial comment on Reemst PHM, et al: SIRS, MODS and tertiary peritonitis. Europ. J. Surg. 162 Supplement 576; 47-49, 1996
• Wittmann DH, Schein M, editorial comment on Bohnen JMA: Postoperative peritonitis. Europ. J. Surg. 162 Supplement 576; 50-52, 1996
• Wittmann DH, Schein M, editorial comment on Frileux P, et al: Pancreatic infections. Europ. J. Surg. 162 Supplement 576; 53-55, 1996
• Wittmann DH, Schein M, editorial comment on Hirshberg A, et al: Penetrating abdominal trauma. Europ. J. Surg. 162 Supplement 576; 56-58, 1996
• Wittmann DH, Schein M, editorial comment on Melcher GA, et al: Blunt abdominal trauma. Europ. J. Surg. 162 Supplement 576; 59-60, 1996
• Wittmann DH, Schein M, editorial comment on Heemken R, et al: Upper gastrointestinal surgery and the appendix. Europ. J. Surg. 162 Supplement 576; 61-62, 1996
• Wittmann DH, Schein M, editorial comment on Fingerhut A, et al: Choice of Antibiotics in two The French Hospitals. Europ. J. Surg. 162 Supplement 576; 63-65, 1996
• Schein M, Wittmann DH, Lorenz W. Forum Statement: a plea for selective and controlled postoperative antibiotic administration Europ. J. Surg. 162 Supplement 576; 66-75, 1996
• Wittmann DH: Postoperative Infections Area Review Paper for Surgical Infection - Index & Review, IV Quarter 1995 : 1197
• Wittmann DH. Comment on Jeroukhimov AD et al Antibiotic prophylaxis in umbilical and incisional hernia repair: a prospective randomized study. Eur. J. Surg 162, 945-948. Surgical Infections: Index & Reviews, 5:I quarter,1997
• Wittmann DH: Comment on Abramov D et al.: Antibiotic prophylaxis in umbilical and incisional hernia repair: a prospective randomized study. European Journal of Surgery 162:945-948, 1996. Surgical Infection - Index & Review, 5: 1;x 1997
• Wittmann DH, Comment on Götzinger, TP, et al.: Does Reoperation for Abdominal Sepsis Enhance the Inflammatory Host Response? Arch Surg. 1997; 132:250-255 -Surgical Infection - Index & Review, 5: 2;x 1997
• Wittmann, DH Comment on: van Goor, H: Complications of Planned Relaparotomy in Patients with Severe General Peritonitis Eur J Surg 1997; 163: 61-66. Surgical Infection - Index & Review, 5: 2;x 1997
• Wittmann DH. Invited Commentary on Abramov et al.: Antibiotic Prophylaxis in Umbilical and Incisional Hernia Repair: A Prospective Randomized Study. Eur. J Surg 1997; 162:945-948. Surgical Infections: Index & Reviews, 5:1,7, 1997

ABSTRACTS

1975-1980

1. Wittmann DH, Schröder HJ. Problems with gallstone ileus.(German) Zbl Chir 100:1015, 1975.

2. Wittmann DH. Two cases of pyodermia sinifica fistulans.(German) Vortrag Nr 37, 118 Tagung Nordwestdeutscher Chirurgen, Hamburg, December 2-4, 1976.

3. Wittmann DH, Boje H, Eckardt K, Niebuhr D. Prognostic significance of mammary gland papillomatosis. (German) Zbl Chir 102:124, 1976.

4. Wittmann DH, Schassan H-H, Fedder J, Rangonwala R. Pharmacokinetic studies with cefuroxime in bone, tissue fluid, peritoneal fluid, and bile. 18th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington DC, Abstract Nr 318, 1978.

5. Wittmann DH, Schassan H-H. Pharmacokinetic Studies and Results of a Clinical Trial with Cefotaxime. 19th Interscience Conference on Antimicrobial Agents and Chemotherapy and 11th International Congress of Chemotherapy Boston, American Society for Microbiology, Washington DC, Abstr Nr 12, 1979.

6. Wittmann DH. Significance of anaerobic bacteria in bile tract infection. (German) In R Häring (Hrsg) Peritonitis TM-Verlag Bad Oyenhausen, pp 83-84, 1979.

7. Wittmann DH. Highly selective vagotomy: a scientific film. (German) Münch med Wschr 121:577-577, 1979.

8. Seidel H, Pfeiffer M, Schimmel G, Wittmann DH. Conservative and operative therapy of grade II and III open tibial fractures. (German) Zbl Chir 104:205, 1979.

9. Wittmann DH, Welter J, Freitag V, Herden N, Schassan H-H. Antimicrobial Therapy for Peritonitis: Results of Peripheral Pharmacokinetics and Clinical Studies. 7th World Congress of Anaesthesiology, Hamburg, 1980, Abstr Nr:, 1980.

10. Wittmann DH, Schassan H-H. Bone levels, tissue fluid and peritoneal fluid measurements following Piperacillin administration. 20th Interscience Conference on Antimicrobial Agents and Chemotherapy American Society for Microbiology New Orleans Poster Abstr 757 American Society for Microbiology Washington DC, 1980.

1981

11. Welter J, Wittmann DH, Freitag V. Combined therapy with cefoxitin and azlocillin in critical care medicine. 12th International Congress of Chemotherapy Florence Abstr Nr 192 International Society of Chemotherapy, 1981.

12. Welter J, Wittmann DH, Schassan H-H. Pharmacokinetic investigations of the penetration of Mezlocillin into the pleural fluid. 12th International Congress of Chemotherapy Florence Abstr Nr 252, International Society of Chemotherapy, 1981.

13. Fedder J, Wittmann DH, Schassan H-H. The influence of protein binding upon tissue fluid levels of Isoxalolyl- and Acylureido- Penicillins. 12th International Congress of Chemotherapy Florence Abstr Nr 257 International Society of Chemotherapy, 1981.

14. Küchlin J, Schassan H-H, Stute J, Wittmann DH. Pharmacokinetic studies and results of a clinical trial with a combination therapy with mezlocillin and oxacillin. 12th International Congress of Chemotherapy Florence Abstr Nr 349, International Society of Chemotherapy, 1981.

15. Wittmann DH, Schassan H-H. Bone concentrations of six new beta-lactam-antibiotics. 12th International Congress of Chemotherapy Florence Abstr Nr 410, International Society of Chemotherapy, 1981.

16. Wittmann DH. Antimicrobial therapy for intra-abdominal infections. (German) In G Rodewald (Ed) 128 Tagung der Vereinigung Norwestdeutscher Chirurgen, Ref 17, Hanseatisches Verlagskontor, Lübeck, 1981.

17. Wittmann DH. Are antimicrobials indicated for prophylaxis of infections after open fractures. (German) In G Rodewald (Ed) 128 Tagung der Vereinigung Norwestdeutscher Chirurgen, Ref 52, Hanseatisches Verlagskontor, Lübeck, 1981.

18. Wittmann DH, Schassan H-H, Kohler F. Results of pharmacokinetic studies with ceftazidime in volunteers and patients. Ceftazidime Symposium, Glaxo Research LTD, Kensington Close, London, Abstr 25, 1981.

19. Wittmann DH. Pharmacokinetic basis for the antimicrobial treatment of surgical infections. (German) Zbl Chir 106:1231, 1981.

20. Wittmann DH, Schassan H-H, Kohler F. The penetration of ceftazidime into bone, bile, tissue fluid and peritoneal fluid. Ceftazidime Symposium, Glaxo Research LTD, Kensington Close, London, Abstr 2, 1981.

1982

21. Wittmann DH. Surgery and antibiotics: clinical selection criteria for adjuvant antimicrobial therapy with beta-lactam antibiotics. (German) Symposium Beta-Lactam-Antibiotika, Gesellschaft Deutscher Chemiker, Frankfurt Feb 19, 1982.

22. Wittmann DH, Welter J, Schassan H-H . Pharmacokinetic investigations upon the penetration of antibiotic into peritoneal fluid. Surgical Infection Society, Programm 2nd Annual Meeting, Abstract 10, 1982.

23. Wittmann DH. Therapy of postoperative infections. (German) 3 Norddeutsche Chemotherapie Konferenz, Travemünde, May 14-15, 1982.

24. Wittmann DH. Intra- und extra-abdominal abscesses: pathogenesis and bacteriology. (German) Tagung der Vereinigung Mittelrheinischer Chirurgen, Kaiserslautern, October 6-8, 1983.

25. Wittmann DH. A Rational Basis for Treating Intra-Abdominal Infection. Guest Lecture, Ass Surg Train Ann General Meeting, Leeds, England, Sept 8-10, 1982.

26. Wittmann DH. Prophylaxis of infections following colon operations: Cefoxitin versus orthograde whole gut lavage. (German) Tagung der Vereinigung Mittelrheinischer Chirurgen, Mannheim October 7-9, 1982.

27. Wittmann DH, Hummel W, Teichmann W. Recurrent peptic ulcer after highly selective vagotomy. (German) Zbl Chir 107:813, 1982.

28. Wittmann DH, Seidel H, Schassan H-H. Concentration determinations of antimicrobial active compounds in bone. (German) Zbl Chir 107:825-826, 1982.

1984

29. Wittmann DH, Huebner A, Fock R, Bauernfeind A. Penetration of pefloxacin into inorganic and organic bone compartments: A cross-over study in elderly. 24th Interscience Conference on Antimicrobial Agents and Chemotherapy American Society for Microbiology Washington DC, 1984.

30. Wittmann DH. Antibiotic concentrations in peritoneal fluid during the vulnerable period of abdominal operations as rational basis for prophylaxis of infections. J Europ Surg Research 161:15-16, 1984.

31. Wittmann DH, Frommelt L. Rational use of antimicrobials in postoperative peritonitis. (German) In G Rodewald (Ed) 134 Tagung der Vereinigung Norwestdeutscher Chirurgen, Ref 5, Hanseatisches Verlagskontor, Lübeck, 1984.

32. Wittmann DH. The role of Cephalosporins in surgical infections. 2nd Meeting of the Society of South East Asian Surgeons, Bangkok, 1984.

1985

33. Teichmann W, Wittmann DH, Simmons RL. Scheduled reoperations (Etappenlavage) for diffuse peritonitis. Prog Fifth Annual Meeting Abstr 28 Surgical Infection Society Delaware USA, 1985.

34. Wittmann DH. Antibiotic concentrations in tissue fluid during the vulnerable period of operations as rationale basis for prophylaxis of infections. 14th International Congress of Chemotherapy, June 23-28, 1985, Kyoto, Japan, International Society of Chemotherapy. SY-8-3:17, 1985

35. Wittmann DH, Teichmann W, Huebner A, Fock R, Bauernfeind A. Penetration of Ciprofloxacin into inorganic and organic bone compartments. Abstracts of the 14th International Congress of Chemotherapy, June 23-28, 1985, Kyoto, Japan, International Society of Chemotherapy. SY-40-7:177.

36. Teichmann W, Wittmann DH, Ziehr T, Dahlke H. The influence of mitomycin-ethiblock on tumor growth of Walker carcinosarcoma. Abstracts of the 14th International Congress of Chemotherapy, June 23-28, 1985, Kyoto, Japan, International Society of Chemotherapy. S-67-9:233, 1985

37. Garweg J, Wittmann DH. Results of a randomized double-blind study in 374 clean neurosurgical operations comparing placebo versus cefamandole to reduce postoperative wound infections. Abstracts of the 14th International Congress of Chemotherapy, June 23-28, 1985, Kyoto, Japan, International Society of Chemotherapy. P-13-71:312., 1985

38. Küchlin J, Berghoff D, Stein G, Kohler W, Wittmann, DH, Frommelt L. Controlled clinical trial on the efficacy of oxacillin versus the combination of oxacillin and mezlocillin in reducing wound and bone infections after open fractures. 14th International Congress of Chemotherapy, Kyoto, Japan, 1985.

39. Wittmann DH. Role of Antibiotics in Surgical Infections. Proc Sixth Conjoint Asia Pacific Congress Karachi Dec pp 85, 1985.

1986

40. Teichmann W, Veit C, Wittmann DH. Planned relaparotomy (Etappenlavage therapy) for necrotizing pancreatitis. (German) Proc 11. Berliner Chirurgentreffens, 1986.

41. Teichmann W, Wittmann DH. Step by step repair for diffuse peritonitis. Abstracts of the XIth Biennial Congress of the International Society of University Colon and Rectal Surgeons, Dallas, TX, May 4-8, 1986.

1987

42. Wittmann DH, Teichmann W. Step by step repair (Etappenlavage) for diffuse peritonitis. 6th Biennial General Scientific Meeting Bangkok Thailand Feb 87, pp 420, Association of Surgeons of Southeast Asia, 1987.

43. Herbig B, Teichmann W, Wittmann DH. Severity scoring for patients undergoing Etappenlavage. In DH Wittmann and J Solomkin (Eds) Program and Book of Abstracts of the International Congress on Intraabdominal Infections. Hamburg, June 1st-3rd. Abstract C-13, 1987.

44. Teichmann W, Wittmann DH, Herbig B. Etappenlavage (Step-by-step repair). In DH

Wittmann and J Solomkin (Eds) Program and Book of Abstracts of the International Congress on Intraabdominal Infections. Hamburg, June 1-3, Abstract H-6, 1987.

1989

45. Koltowski P, Oleskiewicz J, Bergstein JM, Wittmann DH. Controlled trial comparing isepamicin versus amikacin in skin and skin structure infections. 16th International Congress of Chemotherapy, Jerusalem, Israel, Abstracts p 297, 1989.

46. Wittmann DH, Bergstein JM, Edmiston CE, Aprahamian C. Prophylaxis and Therapy of Infections in the Emergency Room with Ceftriaxone. 9th International Congress of Emergency Surgery, Strassbourg, June 26-29, p 364, 1989.

47. Oleskiewicz J, Koltowski P, Jurecki J, Wittmann DH. Efficacy of Bacteriophages and Cefotaxime in Experimental Staphylococcal and Pseudomonal Infections. Surg Res Comm 5S:20, 1989.

48. Wittmann DH, Bergstein JM, Edmiston CE, Aprahamian C: Prophylaxis and Therapy of Infections in the Emergency Room with Ceftriaxone. 9th International Congress of Emergency Surgery, Strassbourg, June 26-29, 1989.

1990

49. Walker ST, Aprahamian CA, Quebbman EJ, Bergstein JM, Wittmann DH, Sasse, EA.. Exposure human immunodeficiency virus positive patients Eastern Assoc. for the Surgery of Trauma, Neaples Meeting, Abstract 6, 1990.

50. Aprahamian C, Wittmann DH, Bergstein JM, Quebbman EJ. Temporary abdominal closure (TAC) for planned relaparotomy (Etappenlavage) in trauma. Eastern Assoc. for the Surgery of Trauma, Naples Meeting, Abstract 38, 1990.

51. Frantzides CT, Lianos EA, Wittmann DH, Greenwood B. In vivo effects of prostaglandines on myoelectric and contractile activities of the small intestine. Gastroenterol 98:A351, 1990.

52. Wittmann DH, Bergstein JM, Aprahamian C, Küchlin J. Broad spectrum Coverage versus Antistaphylococcal prophylaxis alone reduce bone infections after open fractures. Society for Academic Emergency Medicine, Annual Meeting, Abstract 28, 1990.

53. Wittmann DH, Nyström P-O. Multicenter validation of APACHE-II score in intra-abdominal infection. Surg Res Comm 8S:27-28, 1990.

54. Bergstein JM, Kramer A, Wittmann DH, Aprahamian C, Quebbeman EJ. Pseudomembranous enterocolitis: how useful is endoscopy? Surgical Endoscopy 4:59, 1990.

55. Wittmann DH, Bergstein JM, Frantzides C. Prospective randomized trial of pre-operative single shot piperacillin versus single shot moxalactam to prevent infections following colon resections for cancer. 11th World Congress, Collegium Internationale Chirurgiae Disgestivae, New Delhi, India, November 6, 1990.

56. Wittmann DH, Aprahamian C, Bergstein JM. New technique to facilitate Etappenlavage (planned relaparotomies) for abdominal trauma and peritonitis. 11th World Congress, Collegium Internationale Chirurgiae Digestivae, New Delhi, India, November 7, 1990.

57. Aprahamian, CA, Wittmann, DH. Use of Artificial Burr in Planned Re-exploration of the Abdomen. 147th Meeting of The Society of Clinical Surgery, Dept. Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, November 15-17, 1990

1991

58. Oleszkiewicz J, Koltowski P, Dabrowska B,, M. Dabrowski, Wittmann DH:. Bacteriophages compared with amikacin and netilmicin in treatment of experimental vascular prosthetic infections. Surg Res Comm 10:S55, 1991

59. Koltowski P, Oleskiewicz JM, Wittmann DH. Controlled trial comparing Isepamicin versus Amikacin in skin and skin structure infections. Program and Abstracts of the 34th World Congress of Surgery of the ISS/SIC and the 12th World Congress of CICD, Stockholm, Sweden, August 25-31, 1991.

60. Bergstein, JM, Aprahamian CV, Wittmann DH, Quebbeman E, Frantzides C. Narcotics in Endoscopy Survey: Current Practices, Beliefs and Complications. Abstract, Sages: Society of American Gastrointestinal Endoscopic Surgeons, 57:193. Abstract 7, 1991.

1992

61. Wittmann DH, Aprahamian C, Quebbeman EJ, Bergstein JM, Bansal N: Staged Abdominal Repair (STAR) Compares Favorably to Conventional Operative Therapy for Intra-abdominal Infections when Stratified by APACHE-II, Annual Meeting of the Western Trauma Association, Feb. 1992 and Wisconsin Surgical Society

62. Wittmann DH, Aprahamian C, Bergstein JM, Bansal N. Staged Abdominal Repair (STAR) compares favorably to Conventional Operative Therapy for Intra-abdominal Infection when Stratifies by APACHE-II. Twenty-second Annual Meeting of the Western Trauma Association, February 29 - March 7, 1992, Steamboat Springs, Colorado, p 9.

63. Seoane D, Wittmann DH: Outcome Prediction in Intra-Abdominal Infection: Surgeon versus APACHE-II Score , Wisconsin Surgical April 25, 1992, Milwaukee.

64. Bergstein, JM, Seoane D., Wittmann, DH, Quebbeman EJ, Aprahamian C. Duodenal Feeding Tube Placement without Endoscopy or Fluoroscopy. Surgical Endoscopy, Ultrasound and Interventional Techniques 6(2): 107-108, 1992.

1993

65. Ohmann, C, Wittmann, DH, Wacha E. Prospective evaluation of prognostic scoring systems in peritonitis, Fifth Annual Meeting of the Surgical Infection Society - Europe, Santiago de Compostella, 8-10 June 1992, Abstract No. 9, p 17.

66. Ohmann, C, Wittmann, DH, Wacha E. Prospective evaluation of prognostic scoring systems in peritonitis, Fifth Annual Meeting of the Surgical Infection Society - Europe, Santiago de Compostella, 8-10 June 1992, Abstract No. 9, pp 17, 1993.

67. Wittmann DH, Aprahamian C, Bansal N, Bohnen JM, Mustard RA, Schouten BD, Nystroem P-O, Bergstein JM, Quebbeman EJ, Wallace JR: Improved Outcome Prediction Model with APACHE-II Score Derived from 777 Patients with Intra-Abdominal Infection. Annual Meeting of the Western Association for the Surgery of Trauma, Snowbird, Utah, February 28-March 4, 1993..

69. Haasler GB, Aprahamian C, Quebbeman E, Nicolosi A, Wittmann D, Erickson L. Selective Operative Fixation of The Severely Crushed Chest: An Underutilized Option. Society of Thoracic Surgeons, New Orleans, 1-31 to 2-2-94 Presented at Wisconsin Surgical, April 1993

1994

70. Mohme C, Wittmann DH. Quality of well-being Captures Outcome After Trauma. Western Association for the Surgery of Trauma, Crested Butte, CO, 1994.

71. Wittmann DH, Wallace JR, Schein M. Open Abdomen, Planned Relaparotomy or Staged Abdominal Repair: Is There a Difference? Wisconsin Surgical Society Fall Meeting, September 16-17, 1994, Egg Harbor-Door County, Wisconsin.

72. Gardner PM, Vitali CM, Komorowski RA, Clowry LJ, Wittmann DH: Pyodermia fistulans sinifica (fox den disease): A chronic subcutaneous inflammatory disease with complex fistula and tract formation. American Society of Clinical Pathologists. October 24-26, 1994, Washington, DC. Abstract No. 23, page 521.

73. Wittmann DH, Wallace JR, Schein M. Open Abdomen, Planned Relaparotomy or Staged Abdominal Repair: Is There a Difference? Collegium International Chirurgiae Digestivae (CICD) 14th World Congress in Los Angeles, September 28-October 1, 1994. World J Surgery 268:S49, Abstract #243, 1994.

1995

73. Holzheimer RG, Schein M, Wittmann DH: Inflammatory response in peritoneal exudate and plasma of patients undergoing planned relaparotomy for severe secondary peritonitis. Presented at Surgical Infection Society 1995. Louisville, Kentucky, April 19-21, 1995. Arch Surg.

74. Holzheimer R, Schein M, Muhrer K, Molloy R, Wittmann D: Inflammatory mediators in plasma and peritoneal exudate of patients undergoing staged abdominal repair (STAR) for severe peritonitis. Surgical Infection Society - Europe 1995. Freiburg, Germany, June 8-10, 1995. Current Opinion in Surgical Infections Vol 3, Supplement. 1, 1995.

75. Bergstein JM, Gregory JS, Quebbeman EJ, Aprahamian C. Wittmann, DH, Wallace, JR. Extracorporeal Rewarming: Technological Advances and experience in 29 patients: Presented at the Meting of the American Association of Surgery of Trauma, September 27-30, 1995, Halifax, Nova Scotia, Canada

1996

76 Wittmann, DH The abdominal compartment syndrome. 15th World Congress of the Collegium Internationale Chirurgiae Digestivae, Seoul, Korea, September 11-14, 1996.

ABSTRACT of POSTER

1980

1. Wittmann DH, Freitag V, Schassan H-H, Welter J. Studies on the Penetration of Moxalactam into Peritoneal Fluid and its Relevance for Treatment of Intraabdominal Infections. 20th Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, Abstr Nr 247 American Society for Microbiology, Washington DC, 1980.

1981

2. Wittmann DH, Freitag V, Schassan HH, Welter J. Studies on the penetration of Moxalactam into peritoneal fluid and its relevance for treatment of intraabdominal infections. 10 Jahre AKOthmarschen Jubileum, Poster 3, 1981.

3. Wittmann DH. Pharmacokinetics of ceftazidime in volunteers and patients. 10 Jahre AKOthmarschen Jubileum, Poster 4, 1981.

4. Wittmann DH, Schassan H-H, Erich M. Bone levels, tissue fluid and peritoneal fluid levels following piperacillin administration. 10 Jahre AKOthmarschen Jubileum, Poster 2, 1981.

5. Wittmann DH. The selective-proximal vagotomy. (German) 10Jahre AKOthmarschen Jubileum, Poster 1, 1981.

6 Wittmann DH, Teichmann W, Adam D, Rubinstein E, Eggert A. A new method of measuring the protein-unbound fraction of antibiotics in the peritoneal cavity. 21st Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago Poster Abstr 142, American Society for Microbiology, Washington DC, 1981

1982

7. Wittmann DH, Schassan H-H. Concentrations of Cefoperazone in Peritoneal Fluid and Serum. 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy American Society for Microbiology Washington DC, 1982.

8. Wittmann DH, Teichmann W, Welter J, Freitag V. Treatment of Intra-abdominal Infections with Piperacillin Monotherapy. 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Miami, Abstr 404, American Society for Microbiology, Washington, DC, 1982.

1988

9. Wittmann DH, Koltowski P, Oleszkiewicz J, Bergstein JM. Pharmacokinetics of Flomoxef (6315-S) in Patients Concentrations in Serum, Urine, Tissue Fluid, Bile and Peritoneal Fluid. 28th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Abstract 438, 1988

1991

10. Baker EJ, Bergstein JM, Wittmann DH. Bacteriology and treatment of abscesses due to intravenous drug abuse. Surg Res Comm 10S:105, 1991.

1992

11. Wittmann DH, Mueller U. Incidence of Nosocomial Infections in Acute Care Hospitals in the Federal Republic of Germany. Poster presentation at the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy. 11-14 October 1992, Anaheim, California, American Society for Microbiology.

12. Ohmann, C, Wittmann, DH, Wacha E. Prospective evaluation of prognostic scoring systems in peritonitis, Fifth Annual Meeting of the Surgical Infection Society - Europe, Santiago de Compostella, 8-10 June 1992, Abstract No. 9, pp 17.

1993

13. Wittmann DH, Aprahamian C, Quebbeman EJ, Bansal N, Bohnen JM, Mustard RA, Schouten BD, Nystroem PO. Improved outcome predication model with APACHE-II score derived from 777 intra-abdominal infections (IAI) West Presentation 1993, Snowbird, Utah, March 1993.

14. Wittmann DH, Bergstein JM, Georgakas K, Komorowski RA, Quebbeman EJ, Aprahamian C: Pyodermia Fistulans Sinifica: Misdiagnosis Leads to Mistreatment. Poster presentation at Thirteenth Annual Meeting of the Surgical Infection Society. April 29-May 1, 1993, Baltimore, MD.

1996

15 Rodrick, ML, Doherty, JM, Saporoschetz IB, Dunleavy K, Urbaschek RM, Holzheimer, Wittmann DH. Plasma cytokine levels may be altered by therapy with intravenous immunoglubulin in patients following multiple trauma. 16th Annual Meeting of the Surgical Infection Society, April 24-27, 1996, Milwaukee, WI.

FILM

1. DH Wittmann (Ed). Highly selective vagotomy: a scientific film. (German) Produktion Cinedacta Berlin, 1978.
1. Wittmann DH, Bergstein JM, Aprahamian C. Velcro For Temporary Abdominal Closure. 9th International Congress of Emergency Surgery, Strassbourg, June 26-29, Proceedings, p 364, 1989 and CICD Meeting Delhi, India 1982
1. Cherubin C, Fuji S, Guggenbichler JD, Helwig HR, Iannini P, Lecour H, LeFrock J, Lode H, Serra P, Roy S, Wise R, Wittmann DH. Cefotaxime - new clinical breakthroughs. Hoechst Meducation Service, Berlin, 1985.
1. Adam D, Daschner F, Hahn H, Stille W, Wittmann DH. Infection prophylaxis in surgery: a roundtable discussion. (German) Video Film: Reihe Fortbildung in der Infektiologie Takeda Stolberg, 1986.
1. Acar J, Clumeck K, Klastersky J, Neu H, Schield M, Wittmann DH. Current Problems of Nosocomial Infections. Hoechst Meducation Service, Brussels, 1986.
1. Wittmann DH. Planned relaparotomy to treat diffuse peritonitis. (Awarded at the Berlin Meeting of the German Medical Association, translated in three languages) Filmproduktion ARTE-TV Hamburg. Als wissenschaftlich wertvoller Film auf der Tagung für Arztliche Fotbildung in Berlin 1987 ausgezeichnet, 1987
1. Neu H, Gentry L, Wittmann DH. Clinical Management of Post-Traumatic Osteomyelitis: A Round Table Discussion. Video Library on the Management of Gram-positive Infections Healthmark Medical Communications, New York NY, 1987.

INVITED LECTURES, WORKSHOPS, SITE VISITS

1982 University of Mainz, Medical School, Germany

1983 University of Munich, Medical School, Germany

1984 University of Erlangen, Medical School, Germany

1984 Leeds University Medical School, Leeds, England

1985 Wittmann, DH, Antibiotics in early stages of battle field wounds. Meeting of the Senior Medical Officers of the Armed Forces stationed in the Federal Republic of Germany, German Society of Military Medicine and Pharmacy, Führungsakademie der Bundeswehr, Hamburg, June 4th , 1995

1986 Tulane University Medical School, New Orleans

1987 Madras University Medical School, India

1987 University of Indonesia Medical School, Djakarta

1987 Barcelona University Medical School, Spain

1987 II. Chair of Surgery, University of Cologne, Germany

1987 University of Vienna, Medical School, Austria

1987 Bhumipol Hospital, University of Thailand, Bangkok

1987 King Khalid University Hospital, Saudi Arabia

1988 Zürich University Medical School, Switzerland

1988 Kasturba Medical College Nanipal, India

1988 16th Panhellenic Surgical Congress, Athens, Greece.

1988 International Symposium on Anaerobic Bacteria and Bacterial Infections, Monte Carlo.

1988 St. John's Medical College, Bangalore, India

1988 National Taiwan University Hospital Taiwan

1988 Changung Memorial Hospital, Taiwan

1989 University of Wisconsin, Madison

1989 16th International Congress of Chemotherapy, Jerusalem, Israel.

1989 9th International Congress of Emergency Surgery, Strassbourg.

1989 The 33rd World Congress of Surgery, Toronto, Canada.

1990 Michigan State University, Michigan

1990 University of Seoul, Korea

1990 Yon Sei University, College of Medicine, Severance Hospital, Seoul, Korea

1990 Kyung Hee University Medical Center, Seoul, Korea

1990 Korea University, College of Medicine, Hae Wha Hospital, Seoul, Korea

1990 Royal College of Surgeons of Thailand, Bangkok

1990 Khon Keen University Medical School, Khon Keen, Thailand

1991

31 Preparation of Abstracts. 11th Annual Clinic Day, Dept. of Surgery, Medical College of Wisconsin. March 12, 1991.

32 Statistics of Gall stone Disease: Experience 808 Cases. Gallstone Symposium. March 16, 1991, Medical College of Wisconsin.

33. Prophylaxis of Infection following Laparoscopic Cholecystectomy. Wittmann DH. Gallstone Symposium. March 16, 1991, Medical College of Wisconsin.

34 Wittmann DH, Lubbers M, Wacha H. Nyström P-O. Panel on Scoring Systems and Sepsis, Fourth Annual Meeting of the Surgical Infection Society-Europe, Athens, Greece, June 1991

35 Osteomylitis and Infected Prostheses. in R. E. Condon. Serious Surgical Infections in Everyday Practice. Medical College of Wisconsin, Department of Surgery, June 14 and 15, 1991, Madison and Milwaukee.

35 Natural Evolution of Intra-abdominal Septicemia. Post-graduate intensive zorgen. Ortanisatie: Prof. Dr. F. Colardyn. University Hospital of Rijksuniversiteit at Ghent, Belgium. 3 December 1991.

36 Surgical Treatment of Intra-abdominal Infections. Department of Surgery. University of Leuven at Freiburg. December 4, 1991. Guest Lecture.

37. Pathophysiology of Intra-abdominal Infections. Department of Hepatology. University of Leuven at Freiburg. December 4, 1991. Guest Lecture.

38 Definitions and Scoring of Intra-abdominal Infections. Guest Lecture. Freiburg University Medical School. Department of Surgery. December 6, 1991.

1992

39 Advances in Diagnosis and Treatment of Intra-abdominal Infection. Visiting Professor, Grand Rounds Presentation and Syllabus:, St. Luke's Hospital Residency Program, Cleveland, March 21, 1992.

40 Prophylaxis and Antimicrobial Therapy for Surgical Infectious Disease. State Pharmaceutical Administration of China. Beijing and Shanghai, April 2 and 4, 1992.

41 Importance and Role of Prophylactic Antibiotics in Relation to Surgical Procedures. Second European Congress of Surgery. Brussels, June 2-5, 1992.

42 Reducing the Risk of Post-Operative Infection and Sepsis. Second European Congress of Surgery. Brussels, June 2-5, 1992.

43 Protecting Health Care Workers from Infection due to Blood Borne Disease. Fifth Annual Meeting of the Surgical Infection Society - Europe, Santiago de Compostela, June 8-10, 1992.

44. Highly Selective Vagotomy, Still the ideal operation for peptic ulcer disease? Third Annual Symposium Peptic Ulcer Complications. Department of Surgery, Section of Trauma and Emergency Surgery, Medical College of Wisconsin, August 28, 1992.

45. Decision Making in surgery: Use of scoring systems. Colloquium Department of Mathematics, Statistics and Computer Science, Marquette University, Wisconsin, November 19, 1992.

1993

46. Infecciones intraabdominales: Enfoque terapeutico actual XII Curso sobre Infeccion en Cirugia. 29-31 de Marzo do 1993 Santiago de Compostela. Facultad de Medicina, Universidad de Santiago de Compostela.

47 Abdomen Abierto (Open Abdomen). Infeccion en Cirugia. Fundacion Santa Fe de Bogota. Colombia. April 12, 1993.

48. Eleccion antibiotica en pacientes con trauma (Antibiotic selection in patients with trauma). Infeccion en Cirugia. Fundacion Santa Fe de Bogota. Colombia. April 12, 1993.

49. Abdomen Abierto (Laparostomia). IV Curso Urgencias Quirurgicas II Congres. Colombiano de Trauma. Cali, Colombia. April 14-17, 1993.

50. Infeccion en pacientes traumatizados. IV Curso Urgencias Quirurgicas II Congreso Colombiano de Trauma. Cali, Colombia. April 14-17, 1993.

51. Intraabdominal Infection. 56th Congress of Polish Association of Surgeons - Lublin, Poland, May 24, 1993.

52 The Patient With Abdominal Trauma: Lecture presented at Elmbrook Memorial Hospital on Thursday, June 24, 1993

53 Cytokines and other mediators in the pathophysiology of peritonitis. 35th World Congress of International Society of Surgery. International Surgical Week. August 22-27, 1993, Hong Kong.

54 Antibiotic Treatment Of Biliary Infections. 35th World Congress of International Society of Surgery. International Surgical Week. August 22-27, 1993, Hong Kong.

55. Laparostomy, open abdomen, Etappenlavage, planned relaparotomy and staged abdominal repair: Too many names for a new operative method (ISS/SIC). 35th World Congress of International Society of Surgery. International Surgical Week. August 22-27, 1993, Hong Kong.

56. Immunological consequences of antibiotic therapy. In Holzheimer R: Recent Developments in Immunology: Potential Clinical Impact on Surgery and the Treatment of Infections: Presentation in Wurzburg, September 3-4, 1993.

57. Calculated Antimicrobial Therapy of Difficult-To-Treat Surgical Infections, McGill University affiliated hospitals, Montreal, Canada, October 27, 1993.

58. Staged Abdominal Repair for the Treatment of Intra-Abdominal Infections, Grand Rounds, Montreal General Hospital, McGill University, Montreal, Canada, October 28, 1993.

59. Soft Tissue Infection. MCW Emergency Medicine Grand Rounds, November 4, 1993.

60 Relaparotomias Programadas No Tratamento Do Trauma Abdominal (Planned Relaparotomy in Abdominal Trauma), 5th Congresso Brasileiro De Cirurgia Digestiva, November 10-12, 1993, Recife, Brazil.

61 Wittmann DH, Carlos Ernani Rosado Soares (Debatedores). Infeccao em Cirurgia (Infection in Surgery), 5th Congresso Brasileiro De Cirurgia Digestiva, November 10-12, 1993, Recife, Brazil.

62 Profilaxia Das Infeccoes Cirurgicas (Profilaxis of Surgical Infections), 5th Congresso Brasileiro De Cirurgia Digestiva, November 10-12, 1993, Recife, Brazil.

63 Abdome Agudo Nao-Traumatico (Non-Traumatic Acute Abdomen), 5th Congresso Brasileiro De Cirurgia Digestiva, November 10-12, 1993, Recife, Brazil.

1994

64 Definition and scoring as a foundation for research of intra-abdominal infection. National Institute for Research of Neoplastic Diseases. Lima, Peru. February 4, 1994.

65 Antibiotic treatment of abdominal infections. Ecuadorian Society for Surgery. Guayaquil, Ecuador, February 8, 1994.

66. Definition and treatment of intra-abdominal infection. Quito, Ecuador. February 9, 1994.

67. Prevention de la infection postoperativia: Sociedad Colombiana de Cirugia Symposium : Infeccion y antibiotics, Bogota, Feb 11-12, 1994.

68 Mesa Ronde: Infeccion Nosocomial : Sociedad Colombiana de Cirugia Symposium : Infeccion y antibiotics, Bogota, Feb 11-12, 1994

69 Definition indices de servidad coo fundamento para la investigacon en sepsis intraabdominales: Sociedad Colombiana de Cirugia Symposium : Infeccion y antibiotics, Bogota, Feb 11-12, 1994

70 Trauma Care and Health Care Reform. Coalition for American Trauma Care, State Capiton, Washington, DC, February 14, 1994.

71 Update in the Management of Surgical Infections. Bangkok, Royal College of Thai Surgeons (organizer), May 31, 1994.

72 Management of Surgical Infections. Jakarta, Jakarta Hospital and Christian Hospital, June 2, 1994.

73 Antimicrobial Therapy of Intraabdominal Infections. 20th National Congress in Advances in Surgery of the Colombian Society of Surgery. August 16-20, 1994 in the Convention Center Gonzalo Jimenez de Quesada in Santafe De Bogota.

74 Intraabdominal Sepsis. 20th National Congress in Advances in Surgery of the Colombian Society of Surgery. August 16-20, 1994 in the Convention Center Gonzalo Jimenez de Quesada in Santafe De Bogota.

75 Rational Use of Prophylactic Antibiotics. 20th National Congress in Advances in Surgery of the Colombian Society of Surgery. August 16-20, 1994 in the Convention Center Gonzalo Jimenez de Quesada in Santafe De Bogota.

76 Surgery of Intraabdominal Infections. 20th National Congress in Advances in Surgery of the Colombian Society of Surgery. August 16-20, 1994 in the Convention Center Gonzalo Jimenez de Quesada in Santafe De Bogota.

77. Open Abdomen - What is Correct? 20th National Congress in Advances in Surgery of the Colombian Society of Surgery. August 16-20, 1994 in the Convention Center Gonzalo Jimenez de Quesada in Santafe De Bogota.

78. Antibiotics in Abdominal Sepsis. 20th National Congress in Advances in Surgery of the Colombian Society of Surgery. August 16-20, 1994 in the Convention Center Gonzalo Jimenez de Quesada in Santafe De Bogota.

1995

79 Visiting Professor STAR an new operative approach in the Treatment of Intra-abdominal Infections. Grand Round, University of Illinois School of Medicine, Feb. 1995

80. Current concepts in the treatment of infections in surgery. Cefotaxime in the 90's. Bermuda, March 12-13, 1995.

81 State-of-the-art Lecture: New Therapeutic Trends in Intra-abdominal Infection: Symposium on Infections in Surgery: 7th European Congress of Clinical Microbiology and Infectious Disease, Vienna, Austria, March 26-30, 1995: Abstract Nr. 574.

82 Visiting Professor: Operative Management of Abdominal Compartment Syndrome. The University of Tennessee, Memphis, April 26, 1995.

83 Sate-of-the-Art-Lecture The Surgical Management of Peritonitis. Annual Congress of the Association of Surgeons of the Netherlands. Veldhoven, Netherlands, May 18-19, 1995.

84 Surgical approaches to intra-abdominal infection and abdominal compartment syndrome. Lecture given to the Department of Surgery, Gunderson Medical Foundation in La Crosse on July 10th 1995.

85 . Plenary Presentation: AIDS, Hepatitis and the Surgeon: Emergency Surgical Procedures. Thursday, August 31, 1995, 8:30-10 a.m. 36th World Congress of Surgery, International Surgical Week, ISW-95, Lisbon, Portugal, August 27-September 2, 1995.

86 Current Management of Abdominal Infections: Infected Pancreatic Necrosis. Wednesday, 30, 1995, 8:30 a.m. 36th World Congress of Surgery, International Surgical Week, ISW-95, Lisbon, Portugal, August 27-September 2, 1995.

87 Management of Surgical Infection. University of Paris - Department of Infectious Disease, Hôpital Avicenne, 125, Route de Stalingrad - 93000 Bobigny - Paris 13 [Professor Robineau].

88. Pathophysiology of abdominal compartment syndrome. University of Amiens, Centre Hospitalier Universitaire d'Amiens - Place Victor Pauchet - 8000 Amiens (Professor Jean-Luc Schmitt).

89. Antibiotic prophylaxis and treatment of surgical infections. University of Amiens, Centre Hospitalier Universitaire d'Amiens - Place Victor Pauchet - 8000 Amiens (Professor Jean-Luc Schmitt).

90. Infectious problems in minimally invasive surgery. 3rd meeting of the Association of European Young Medical Scientists. September 15-17, 1995, Gdansk, Poland.

91. Physiology of abdominal compartment syndrome and STAR. 3rd meeting of the Association of European Young Medical Scientists. September 15-17, 1995, Gdansk, Poland.

1996

92. How to discuss a paper. 16th Annual Clinic Day; the annual resident competition symposium, organized by the section of Trauma and Emergency Surgery, Department of Surgery, Medical College of Wisconsin. April 10, 1996.

93. Pharmacokinetics of locally and systematically applied antibiotics: Symposium on Progress in the Treatment of Surgical Infections. 6th BICON. Leipzig, May 2-4, 1996.

94. Antibiotic therapy in spontaneous, post-operative and post-traumatic intraabdominal infections: Empirical or calculated? Symposium on Empirical therapy of Hospital-Acquired infections. 6th BICON. Leipzig, May 2-4, 1996.

95. Preventing infectious complications after generalized peritonitis. Symposium on Facing the Challenge of Post-Operative Infection after Colorectal Surgery, CIPI 4th International Conference on the Prevention of Infection, May 6-7, 1996, Nice, France.

96. AIDS and Emergency Surgical Procedures. Symposium on AIDS, Hepatitis, the Patient and the Surgeon, CIPI 4th International Conference on the Prevention of Infection, May 6-7, 1996, Nice, France

97. Abdominal compartment syndrome. State-of-the-art Lecture, Annual Congress of the Turkish Surgical Society , Antalya, Turkey, May 15-19, 1996

98. Antibiotic Prophylaxis in Surgery: (Luncheon Panel) Annual Turkish Surgical Congress, Antalya, Turkey May 15-19, 1996

99. Akute Aspekte der Therapie mit Antibiotika in einer Chirurgischen Klinik. Universität Jena, Hörsaal der Chirurgischen Klinik, June 6th, 1996

100 Post-surgical infections and surgical prophylaxis . Lecture, 7th International Congress for Infectious Diseases, Hongkong, June 10th - 13th 1996, Hongkong

101 Cefotaxime – Benefits in surgery: in post-surgical infections and in surgical prophylaxis. Lecture, 7^th International Congress for Infectious Diseases, Honk Kong, June 10-13, 1997 (#363c)

102 Prophylaxis and Treatment of Surgical Infection: Shanghai Second Medical University, Shanghai, China, September 11, 1996

103 Prophylaxis and Treatment of Surgical Infection: Nanjing Medical University, Nanjing, China, September 12, 1996

104 Prophylaxis and Treatment of Surgical Infection: Peking Union Medical College Hospital, Second Medical University, Bejing, China, September 13, 1996

105 Abdominal Compartment Syndrome. 15th World Congress of the Collegium Internationale Chirurgiae Digestivae, Seoul, Korea, September 11-14, 1996

106 Surgical Infection - An Issue? Medical College of Wisconsin Farewell Symposium for R.E. Condon (Condon Fest). Milwaukee,. September 20 - 21, 1996

107 Initiative for the foundation of a Wisconsin Chamber of Physicians and Surgeons to face the challenges in the new health care environment. September 26, 1996, Ohio Medical Association, Columbus, Ohio.

108 Abdominal Compartment Syndrome and Pathophysiology and Treatment of Peritonitis: Visiting Professor September 27, 1996, Mt. Carmel Health Care Center, Columbus, Ohio.

109 The HMO Battle. Ohio State Surgical Society, Columbus, Ohio. September 27, 1996

110 Surgery for intra-abdominal sepsis: VII^th Post Graduate Course on Emergencies in Gastroenterology and Hepatology December 6-7, 1996, University of Leuven, Leuven, Belgium.

111 Treatment of acute pancreatitis: State of the Art Lecture, December 16, 1996, 7th United Arab Emirates Annual Surgical Conference, December 14-17, 1996, Sharjah, UAE.

112 Impact of Abdominal Compartment Syndrome on operative Management of intraabdominal sepsis: State of the Art Lecture, December 16, 1996, 7th United Arab Emirates Annual Surgical Conference, December 14-17, 1996, Sharjah

113 Impact of abdominal compartment syndrome on the management of secondary peritonitis. Invited speaker, Symposium on Intra Abdominal Infections, March 12, 1997, Fairview Hospital, Cleveland, Ohio.

114 Operative and non-operative management of acute pancreatitis. Invited speaker, Symposium on Intra Abdominal Infections, March 12 ,1997, Fairview Hospital, Cleveland, Ohio.

115. 
     
116. Does Infection Surveillance make a difference? Pro: M. Cainzos, Spain, Contra: DH Wittmann. 10^th Annual Meeting of the Surgical Infection Society - Europe in Istanbul, Turkey, May 29- 31, 1997.
117. 
     
118. 10^th Anniversary of the Infection Society Europe: Honorary Lecture at the10^th Annual Meeting of the Surgical Infection Society - Europe in Istanbul, Turkey, May 29- 31
119. 
     
120. Plenary Lecture on therapeutic aspects in intra-abdominal infection: The challenge of intra-abdominal infections and recent developments in immunology and microbiology and their impact on clinical studies: Symposium of the European Research Network on Surgical Infections, Heidelberg, Weinheim, September 5-7, 1997
121. 
     
122. Operative and Non-operative Management of Acute Pancreatitis., Lecture and Grand Rounds university of Indonesia, Jakarta 9/11/97
123. 
     
124. Prophylaxis and Treatment of Surgical Infections – USA Experience. Symposium: Persistent Challenge to Sepsis. Lecture and Grand Rounds University of Indonesia, Jakarta September 1997
125. 
     
126. Prophylaxis and Treatment of Surgical Infections – USA Experience. 15 Years Claforan Anniversary Symposia. Indonesia. Symposium I, Jakarta March 1997
127. 
     
128. Cefotaxime: The Past, The Present and the Future and its Place Among Fourth Generation Cephalosporins, with Particular Emphasis on Meningitis. Lecture Delivered for Dr. Walter Wilson. 15 Years Claforan Anniversary Symposia. Indonesia. Symposium II, Surahaya, East Java March 1997
129. 
     
130. Plenary Lecture: Prophylaxis of post-operative surgical infections. Invited speaker, XXII Brazilian Congress of Surgery. Brazil, 9/22/97
131. 
     
132. Compartmentalization of cytokines in the abdominal cavity. (workshop) . Invited speaker, XXII Brazilian Congress of Surgery. Brazil, 9/23/97
133. 
     
134. New methods of operative management of intra-abdominal infections . Invited speaker, XXII Brazilian Congress of Surgery. Brazil, 9/24/97
135. 
     
136. Sepsis Syndrome without trauma. Invited speaker, Roundtable Discussion. XXII Brazilian Congress of Surgery. Brazil, 9/23/97
137. 
     
138. Dynamic Antibiotic Switching (D.A.S.) And Other New Approaches In Anti-Microbial Therapy. Medical College of Wisconsin, 11/4/97.
139. 
     
140. Infection and Trauma: Panel Discussion. Moderated by Dietmar H. Wittmann, MD, Ph.D. Medical College of Wisconsin, 11/4/97.
141. 
     
142. Prophylaxis of post-operative infections. Lecture delivered University of Belém, Brazil, 9/25/97
143. 
     
144. Principles of operative and non-operative therapy of intra-abdominal infections. Lecture delivered University of Belém, Brazil, 9/25/97
145. 
     
146. The Abdominal Compartment Syndrome. Lecture delivered in Ankara, Surgical Infection Society Europe, 3/20/98.
147. 
     
148. Surgical Treatment of Intra-Abdominal Infection. . Lecture delivered in Ankara, Surgical Infection Society Europe, 3/20/98.
149. 
     
150. SIS Working Group: The Evaluation of Source Control in Clinical Trials, New, NY, May 2-3-1998
151. 
     
152. Resistant Gram-positive Bacteria and Infections: Panel sponsored by the Advisory Councils of the American College of Surgeons: Drug-Resistant Bacterial Infections: The Misuse of Antibiotics. 1998 Clinical Congress, Orlando, Fl. Wednesday Oct. 28. 1998

CHAIRMAN

1983 Symposium: Bone Infections, Vienna, Austria

1983 Symposium on Metronidazole, Baden Baden, West Germany

1984 Symposium on Surgical Infections, Frankfurt, West Germany

1986 Annual Meeting of the Paul Ehrlich Society (German Infectious Disease Society) Frankfurt, Germany, Chairman of Scientific Program

1987 International Congress on Intraabdominal Infections, Hamburg, Germany, Congress Chairman

1987 Controversies in Abdominal Surgery: Post-operative Complications, Vienna, Austria

1988 Symposium on Surgical Infections, Annual Meeting of the Asian Surgical Association, Bangkok, Thailand

1989 WHO-Symposium on the Worldwide Abuse of Antibiotics, Freiburg, Germany

1990 Advances in Trauma Care, Medical College of Wisconsin

1990 Infections in Gastrointestinal Surgery, 11th Congress, Collegium Internationale Chirurgiae Digestivae, New Delhi, India

1991 Gallstone Symposium, Medical College of Wisconsin

1992 Chairman: Third Annual Symposium Peptic Ulcer Complications. Department of Surgery, Section of Trauma and Emergency Surgery, Medical College of Wisconsin, August 28, 1992.

1993 Chairman; Fourth Annual Symposium on Critical Care and Emergency Surgery Pancreatitis. Medical College of Wisconsin Department of Surgery, 1993

1993 35th World Congress of International Society of Surgery, Hong Kong

1993 International Congress on Recent Developments in Immunology, Potential Clinical Impact on Surgery and the Treatment of Infections, Chirurgische Universitätsklinik Würzburg, Würzburg, Germany

1993 56th Congress of the Society of Polish Surgeons, Medical Academy of Lublin, Lublin, Poland

1993 Abdome Agudo Nao-Traumatico (Non-Traumatic Acute Abdomen), 5th Congresso Brasileiro De Cirurgia Digestiva, November 10-12, 1993, Recife, Brazil.

1994 Definition indices de servidad coo fundamento para la investigacon en sepsis intraabdominales: Sociedad Colombiana de Cirugia Symposium : Infeccion y antibiotics, Bogota, Feb 11-12, 1994

1995

1995 Symposium on Infections in Surgery: 7th European Congress of Clinical Microbiology and Infectious Disease, Vienna, Austria

1995 Debate Chairman: Infection vs. Inflammation in the Pathogenesis of MODS (Panelists JA Goris and RW Yurt). Surgical Infection Society, Freiburg, Germany, June 8-10,

1985 Moderator Luncheon Panel Abdominal Compartment Syndrome. Friday, September 1, 1995, 12:15 p.m. 36th World Congress of Surgery, International Surgical Week, ISW-95, Lisbon, Portugal, August 27-September 2, 1995.

1995 Moderator, Luncheon Panel: Streptococcal soft tissue infection. 36th World Congress of Surgery, International Surgical Week, ISW-95, Lisbon, Portugal, August 27-September 2, 1995.

1996

Symposium on Progress in the Treatment of Surgical Infections. 6th BICON, Leipzig, Germany, May 2-4, 1996. BICON

Symposium on AIDS, Hepatitis, the Patient and the Surgeon, CIPI 4th International Conference on the Prevention of Infection, May 6-7, 1996, Nice, France

Free paper session IV, 9the Annual Meeting of the Surgical Infections Society Europe, Paris May 30 to June 1st, 1996

Symposium #16: Surgical infection and digestive system. 15th World Congress of the Collegium Internationale Chirurgiae Digestivae, Seoul, Korea, September 11-14, 1996.

Session 1 : Approach to the patient with acute abdomen. Guest Moderator, Emergencies in Gastroenterology and Hepatology Symposium, December 6-7, 1996, University of Leuven, Leuven, Belgium.

1997

Symposium: Persistent Challenge to Sepsis, September 13, 1997, Indonesia

Session IV. Cooperation in clinical research between university and industry. Evaluation and strategy . Symposium of the European Research Network on Surgical Infections: The challenge of intra-abdominal infections and recent developments in immunology and microbiology and their impact on clinical studies:, Heidelberg, Weinheim, September 5-7, 1997

Trauma Symposium: Infection and Trauma. Medical College of Wisconsin, November 4-5, 1997.

1998

Advanced Course, Surgical Infection and Inflammation. Surgical Infection Society – Europe. Ankara, Turkey 3/18-21, 1998.

Panel on the Treatment of Intra-abdominal Infection, 11^th Annual Meeting ogf the Surgical Infections Society Europe (SIS-E), London, May 1998

Panel on the Multiresitand Bacteria; American College Of Surgeons Clinical Congress 1998, Orlando, Oct 1998

Portugal Lectures and Panel Nov 1998